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    pncA nicotinamidase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946276, updated on 17-Dec-2024

    Summary

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    Official Symbol
    pncA
    Official Full Name
    nicotinamidase
    Primary source
    ECOCYC:EG11135
    Locus tag
    b1768
    See related
    ASAP:ABE-0005891
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1766; nam; ydjB
    Summary
    PncA: [More information is available at EcoCyc: EG11135].
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    Genomic context

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    Sequence:
    NC_000913.3 (1851887..1852528)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene protease IV, a signal peptide peptidase Neighboring gene L-asparaginase 1 Neighboring gene putative transporter YdjE Neighboring gene putative DNA-binding transcriptional regulator YdjF

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of CobB kinetics and inhibition by nicotinamide. Gallego-Jara J, et al. PLoS One, 2017. PMID 29253849, Free PMC Article
    2. Identification, cloning, and expression of the Escherichia coli pyrazinamidase and nicotinamidase gene, pncA. Frothingham R, et al. Antimicrob Agents Chemother, 1996 Jun. PMID 8726014, Free PMC Article
    3. Hyperproduction and purification of nicotinamide deamidase, a microconstitutive enzyme of Escherichia coli. Pardee AB, et al. J Biol Chem, 1971 Nov 25. PMID 4399474
    4. Pyridine nucleotide metabolism in Escherichia coli. IV. Turnover. Manlapaz-Fernandez P, et al. J Biol Chem, 1973 Jul 25. PMID 4146189
    5. Pyridine nucleotide metabolism in Escherichia coli. 3. Biosynthesis from alternative precursors in vivo. McLaren J, et al. J Biol Chem, 1973 Jul 25. PMID 4146188

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nicotinamidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nicotinamidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in pyridine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pyridine nucleotide salvage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nicotinamidase
    NP_416282.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1851887..1852528
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416282.4 nicotinamidase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416282.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1X3JG59
      Conserved Domains (1) summary
      PRK11609
      Location:4 → 213
      PRK11609; bifunctional nicotinamidase/pyrazinamidase
    Nucleotide Protein
    Heading Accession and Version

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