ruvB Holliday junction branch migration complex subunit RuvB [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Official Symbol: ruvB
Official Full Name: Holliday junction branch migration complex subunit RuvB
Primary source: ECOCYC:RUVB
Locus tag: b1860
See related: ASAP:ABE-0006204
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK1861
Summary: May directly convert replication forks into Holliday junctions. [More information is available at EcoGene: EG10924]. RuvABC is an enzymatic complex which functions in recombination pathways by binding to recombinational junctions and catalyzing strand cleavage and branch migration. [More information is available at EcoCyc: RUVB].
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Genomic context

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Sequence:: NC_000913.3 (1944346..1945356, complement)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The rarA gene as part of an expanded RecFOR recombination pathway: Negative epistasis and synthetic lethality with ruvB, recG, and recQ.
Title: The rarA gene as part of an expanded RecFOR recombination pathway: Negative epistasis and synthetic lethality with ruvB, recG, and recQ.
Regression of replication forks stalled by leading-strand template damage: both RecG and RuvAB catalyze regression, but RuvC cleaves the holliday junctions formed by RecG preferentially.
Title: Regression of replication forks stalled by leading-strand template damage: I. Both RecG and RuvAB catalyze regression, but RuvC cleaves the holliday junctions formed by RecG preferentially.
RNA polymerase mutations reduce the synergism between priB and ruvABC.
Title: Modulation of DNA damage tolerance in Escherichia coli recG and ruv strains by mutations affecting PriB, the ribosome and RNA polymerase.
DNA fragmentation absolutely depends on both RecA-catalyzed homologous strand exchange and RuvABC-catalyzed Holliday junction resolution
Title: Replication forks stalled at ultraviolet lesions are rescued via RecA and RuvABC protein-catalyzed disintegration in Escherichia coli.
Study hypothesized that RuvAB catalyzes replication fork reversal in order to produce SOS(Con) expression.
Title: RecA4142 causes SOS constitutive expression by loading onto reversed replication forks in Escherichia coli K-12.
The authors present here the isolation and characterization of ruvA and ruvB single mutants that are impaired for replication fork reversal at forks arrested by the inactivation of polymerase III, while they remain capable of homologous recombination.
Title: ruvA and ruvB mutants specifically impaired for replication fork reversal.
RuvABC is required to resolve junctions that arise during the repair of a subset of nonarresting lesions after replication has passed through the template
Title: RuvABC is required to resolve holliday junctions that accumulate following replication on damaged templates in Escherichia coli.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables DNA helicase activity	IDA Inferred from Direct Assay more info	PubMed
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables forked DNA-dependent helicase activity	IEA Inferred from Electronic Annotation more info
enables four-way junction DNA binding	IEA Inferred from Electronic Annotation more info
enables four-way junction helicase activity	IDA Inferred from Direct Assay more info	PubMed
enables four-way junction helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded 3'-5' DNA helicase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA duplex unwinding	IEA Inferred from Electronic Annotation more info
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in SOS response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within SOS response	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within SOS response	RCA inferred from Reviewed Computational Analysis more info	PubMed
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in recombinational repair	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within recombinational repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in recombinational repair	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to UV	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Holliday junction helicase complex	IPI Inferred from Physical Interaction more info	PubMed
part_of Holliday junction resolvase complex	IDA Inferred from Direct Assay more info	PubMed
part_of Holliday junction resolvase complex	IEA Inferred from Electronic Annotation more info
part_of Holliday junction resolvase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Holliday junction branch migration complex subunit RuvB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000913.3 Reference assembly

Range

1944346..1945356 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_416374.1 Holliday junction branch migration complex subunit RuvB [Escherichia coli str. K-12 substr. MG1655]

See identical proteins and their annotated locations for NP_416374.1

Status: PROVISIONAL

UniProtKB/TrEMBL

A0A6M9WPV1

Conserved Domains (1) summary

PRK00080
Location:6 → 332

ruvB; Holliday junction branch migration DNA helicase RuvB