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    ubiX flavin prenyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 949033, updated on 17-Dec-2024

    Summary

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    Official Symbol
    ubiX
    Official Full Name
    flavin prenyltransferase
    Primary source
    ECOCYC:EG11044
    Locus tag
    b2311
    See related
    ASAP:ABE-0007628
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    dedF; ECK2305
    Summary
    Genetic interactions between ubiX and ubiG as well as their mutant phenotypes indicate that UbiX and UbiG must interact to be able to carry out the 3-octaprenyl-4-hydroxybenzoate decarboxylase step in ubiquinone biosynthesis during logarithmic growth. [More information is available at EcoCyc: EG11044].
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    Genomic context

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    Sequence:
    NC_000913.3 (2428057..2428626, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene histidine ABC transporter periplasmic binding protein Neighboring gene lysine/arginine/ornithine ABC transporter periplasmic binding protein Neighboring gene amidophosphoribosyltransferase Neighboring gene colicin V production protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phenotypic alteration and target gene identification using combinatorial libraries of zinc finger proteins in prokaryotic cells. Park KS, et al. J Bacteriol, 2005 Aug. PMID 16030245, Free PMC Article
    2. Regulation of Escherichia coli purF. Analysis of the control region of a pur regulon gene. Makaroff CA, et al. J Biol Chem, 1985 Aug 25. PMID 2991286
    3. Low ubiquinone content in Escherichia coli causes thiol hypersensitivity. Zeng H, et al. J Bacteriol, 1998 Jul. PMID 9658014, Free PMC Article
    4. Genetic evidence for an interaction of the UbiG O-methyltransferase with UbiX in Escherichia coli coenzyme Q biosynthesis. Gulmezian M, et al. J Bacteriol, 2006 Sep. PMID 16923914, Free PMC Article
    5. Isofunctional enzymes PAD1 and UbiX catalyze formation of a novel cofactor required by ferulic acid decarboxylase and 4-hydroxy-3-polyprenylbenzoic acid decarboxylase. Lin F, et al. ACS Chem Biol, 2015 Apr 17. PMID 25647642

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables carboxy-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin prenyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables flavin prenyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin prenyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables prenyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in prenyl-FMNH2 biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ubiquinone biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ubiquinone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    flavin prenyltransferase
    NP_416814.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2428057..2428626 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416814.1 flavin prenyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416814.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376RFC3
      Conserved Domains (1) summary
      PRK06029
      Location:1 → 187
      PRK06029; UbiX family flavin prenyltransferase
    Nucleotide Protein
    Heading Accession and Version

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