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    mntH Mn(2(+))/Fe(2(+)): H(+) symporter MntH [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946899, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mntH
    Official Full Name
    Mn(2(+))/Fe(2(+)): H(+) symporter MntH
    Primary source
    ECOCYC:G7254
    Locus tag
    b2392
    See related
    ASAP:ABE-0007889
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2387; mntA; yfeP
    Summary
    Fur and OxyR regulons. [More information is available at EcoGene: EG14157]. The MntH protein is a member of the natural resistance-associated macrophage proteins (NRAMP) family of metal ion transporters. [More information is available at EcoCyc: G7254].
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    Genomic context

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    Sequence:
    NC_000913.3 (2511468..2512706, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transport protein YfeO Neighboring gene DUF2502 domain-containing protein YpeC Neighboring gene protein YpeD Neighboring gene nucleoside:H(+) symporter NupC Neighboring gene putative IS186/IS421 transposase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence that highly conserved residues of transmembrane segment 6 of Escherichia coli MntH are important for transport activity. Haemig HA, et al. Biochemistry, 2010 Jun 8. PMID 20441230, Free PMC Article
    2. Determination of transmembrane topology of the Escherichia coli natural resistance-associated macrophage protein (Nramp) ortholog. Courville P, et al. J Biol Chem, 2004 Jan 30. PMID 14607838
    3. Horizontal gene transfer of "prototype" Nramp in bacteria. Richer E, et al. J Mol Evol, 2003 Oct. PMID 14708570
    4. Importance of conserved acidic residues in mntH, the Nramp homolog of Escherichia coli. Haemig HA, et al. J Membr Biol, 2004 Sep 15. PMID 15630547
    5. Solute carrier 11 cation symport requires distinct residues in transmembrane helices 1 and 6. Courville P, et al. J Biol Chem, 2008 Apr 11. PMID 18227061

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Synthetic peptides corresponding to the sixth transmembrane segment of MntH(Proton-dependent Manganese Transporter) and its two mutations in the functionally important conserved histidine residue were used as a model for structure-function study of MntH.
      Title: Ion channel activity of transmembrane segment 6 of Escherichia coli proton-dependent manganese transporter.
    2. Multiple conserved residues on transmembrane segment 6 of MntH may comprise an important face that is critical for protein
      Title: Evidence that highly conserved residues of transmembrane segment 6 of Escherichia coli MntH are important for transport activity.
    3. Failure to induce MntH results in a profound growth defect during H2O2 stress, and mutants that cannot import manganese are unable to sequester iron.
      Title: Manganese import is a key element of the OxyR response to hydrogen peroxide in Escherichia coli.
    4. Study reveals structural and functional roles for four Nramp-specific transmembrane residues in MntH that may have contributed to the emergence of this family of metal and proton cotransporters.
      Title: Identification of functional amino acids in the Nramp family by a combination of evolutionary analysis and biophysical studies of metal and proton cotransport in vivo.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables cadmium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cadmium ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables manganese ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables manganese ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables manganese ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables proton transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cadmium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cadmium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cadmium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within cobalt ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in iron ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within iron ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in manganese import into cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in manganese ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within manganese ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in metal ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within metal ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mn(2(+))/Fe(2(+)): H(+) symporter MntH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2511468..2512706 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416893.1 Mn(2(+))/Fe(2(+)): H(+) symporter MntH [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416893.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T5ZHE2
      Conserved Domains (1) summary
      PRK00701
      Location:1 → 412
      PRK00701; divalent metal cation transporter MntH
    Nucleotide Protein
    Heading Accession and Version

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