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    gudD D-glucarate dehydratase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947258, updated on 17-Dec-2024

    Summary

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    Official Symbol
    gudD
    Official Full Name
    D-glucarate dehydratase
    Primary source
    ECOCYC:G7445
    Locus tag
    b2787
    See related
    ASAP:ABE-0009134
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2781; ygcX
    Summary
    D-glucarate dehydratase catalyzes the dehydration of D-glucarate to 5-keto-4-deoxy-D-glucarate (KDG). [More information is available at EcoCyc: G7445].
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    Genomic context

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    Sequence:
    NC_000913.3 (2918045..2919385, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 23S rRNA m(5)U1939 methyltransferase Neighboring gene sensor histidine kinase BarA Neighboring gene glucarate dehydratase-related protein Neighboring gene galactarate/D-glucarate transporter GudP

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bacterial conversion of D-glucarate to glycerate and pyruvate. BLUMENTHAL HJ, et al. Biochem Biophys Res Commun, 1963 May 3. PMID 13971911
    2. Evolution of enzymatic activities in the enolase superfamily: crystallographic and mutagenesis studies of the reaction catalyzed by D-glucarate dehydratase from Escherichia coli. Gulick AM, et al. Biochemistry, 2000 Apr 25. PMID 10769114
    3. Two genes affecting glucarate utilization in Escherichia coli K12. Roberton AM, et al. J Gen Microbiol, 1980 Apr. PMID 6999115
    4. Evolution of enzymatic activities in the enolase superfamily: identification of the general acid catalyst in the active site of D-glucarate dehydratase from Escherichia coli. Gulick AM, et al. Biochemistry, 2001 Aug 28. PMID 11513584
    5. A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Lasserre JP, et al. Electrophoresis, 2006 Aug. PMID 16858726

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Evolution of enzymatic activities in the enolase superfamily: characterization of the (D)-glucarate/galactarate catabolic pathway in Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables glucarate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucarate dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glucarate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-glucarate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within D-glucarate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in D-glucarate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in D-glucarate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glucarate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    D-glucarate dehydratase
    NP_417267.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2918045..2919385 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417267.1 D-glucarate dehydratase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417267.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376RDH0, A0A775YV54
      Conserved Domains (1) summary
      TIGR03247
      Location:5 → 446
      glucar-dehydr; glucarate dehydratase
    Nucleotide Protein
    Heading Accession and Version

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