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    ygdG flap endonuclease [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947256, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ygdG
    Official Full Name
    flap endonuclease
    Primary source
    ECOCYC:EG12372
    Locus tag
    b2798
    See related
    ASAP:ABE-0009174
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2793; exo; xni
    Summary
    The previously reported exonuclease activity of YgdG(Xni) has been refuted due to copurification with ExoIII (Xth) (Shafritz, 1998; Hodskinson, 2007). [More information is available at EcoGene: EG12372]. YgdG is a protein of unknown function that interacts with exonuclease III and SSB, and was previously identified as an exonuclease itself. [More information is available at EcoCyc: EG12372].
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    Genomic context

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    Sequence:
    NC_000913.3 (2931055..2931810)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene L-serine:H(+) symporter SdaC Neighboring gene L-serine deaminase II Neighboring gene L-1,2-propanediol oxidoreductase Neighboring gene L-fuculose-phosphate aldolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The structure of Escherichia coli ExoIX--implications for DNA binding and catalysis in flap endonucleases. Anstey-Gilbert CS, et al. Nucleic Acids Res, 2013 Sep. PMID 23821668, Free PMC Article
    2. xni-deficient Escherichia coli are proficient for recombination and multiple pathways of repair. Lombardo MJ, et al. DNA Repair (Amst), 2003 Nov 21. PMID 14599740
    3. Exonuclease IX of Escherichia coli removes 3' phosphoglycolate end groups from DNA. Sandigursky M, et al. Radiat Res, 1998 Dec. PMID 9840179
    4. Computer aided identification of a potential 5'-3' exonuclease gene encoded by Escherichia coli. Sayers JR. J Theor Biol, 1994 Oct 21. PMID 7996866
    5. Sequencing and characterization of the sdaB gene from Escherichia coli K-12. Shao Z, et al. Eur J Biochem, 1993 Mar 15. PMID 8385012

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The associated 3'-5' exodeoxyribonuclease activity of Escherichia coli ExoIX was separated from it by liquid chromatography and identified as exonuclease III.
      Title: Molecular interactions of Escherichia coli ExoIX and identification of its associated 3'-5' exonuclease activity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 5'-3' exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 5'-flap endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-flap endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5'-flap endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity, acting on a nucleic acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables potassium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication, Okazaki fragment processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication, Okazaki fragment processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA replication, Okazaki fragment processing IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    flap endonuclease

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2931055..2931810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417278.4 flap endonuclease [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417278.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0H0GBP1
      Conserved Domains (1) summary
      PRK09482
      Location:1 → 251
      PRK09482; flap endonuclease-like protein; Provisional
    Nucleotide Protein
    Heading Accession and Version

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