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    hemW heme chaperone HemW [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947446, updated on 3-Dec-2024

    Summary

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    Official Symbol
    hemW
    Official Full Name
    heme chaperone HemW
    Primary source
    ECOCYC:G7531
    Locus tag
    b2955
    See related
    ASAP:ABE-0009694
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2950; yggW
    Summary
    YggW has three predicted Fe-binding iron-sulfur centers and seven predicted SAM binding sites. [More information is available at EcoGene: EG12983].
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    Genomic context

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    Sequence:
    NC_000913.3 (3097267..3098403)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene PLP homeostasis protein Neighboring gene uncharacterized protein YggT Neighboring gene DUF167 domain-containing protein YggU Neighboring gene dITP/XTP pyrophosphatase Neighboring gene DUF1202 domain-containing protein YggM Neighboring gene L-asparaginase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional and proteomic analysis of a ferric uptake regulator (fur) mutant of Shewanella oneidensis: possible involvement of fur in energy metabolism, transcriptional regulation, and oxidative stress. Thompson DK, et al. Appl Environ Microbiol, 2002 Feb. PMID 11823232, Free PMC Article
    2. Regulon and promoter analysis of the E. coli heat-shock factor, sigma32, reveals a multifaceted cellular response to heat stress. Nonaka G, et al. Genes Dev, 2006 Jul 1. PMID 16818608, Free PMC Article
    3. The binary protein-protein interaction landscape of Escherichia coli. Rajagopala SV, et al. Nat Biotechnol, 2014 Mar. PMID 24561554, Free PMC Article
    4. The radical SAM protein HemW is a heme chaperone. Haskamp V, et al. J Biol Chem, 2018 Feb 16. PMID 29282292, Free PMC Article
    5. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables coproporphyrinogen oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in porphyrin-containing compound biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in porphyrin-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in porphyrin-containing compound biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    heme chaperone HemW

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3097267..3098403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417430.1 heme chaperone HemW [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417430.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A775TGG8
      Conserved Domains (1) summary
      PRK05660
      Location:1 → 378
      PRK05660; radical SAM family heme chaperone HemW
    Nucleotide Protein
    Heading Accession and Version

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