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    nudF ADP-sugar pyrophosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947519, updated on 3-Dec-2024

    Summary

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    Official Symbol
    nudF
    Official Full Name
    ADP-sugar pyrophosphatase
    Primary source
    ECOCYC:EG12633
    Locus tag
    b3034
    See related
    ASAP:ABE-0009961
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    aspP; ECK3025; trgB; yqiE
    Summary
    Nudix hydrolase. [More information is available at EcoGene: EG12184]. ADP-glucose is a precursor molecule for glycogen biosynthesis. [More information is available at EcoCyc: EG12633].
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    Genomic context

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    Sequence:
    NC_000913.3 (3177281..3177910, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene esterase YqiA Neighboring gene cAMP phosphodiesterase Neighboring gene DUF1249 domain-containing protein YqiB Neighboring gene outer membrane channel TolC Neighboring gene DUF1190 domain-containing protein YgiB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cytoplasmic Escherichia coli ADP sugar pyrophosphatase binds to cell membranes in response to extracellular signals as the cell population density increases. Morán-Zorzano MT, et al. FEMS Microbiol Lett, 2008 Nov. PMID 18778276
    2. Escherichia coli AspP activity is enhanced by macromolecular crowding and by both glucose-1,6-bisphosphate and nucleotide-sugars. Morán-Zorzano MT, et al. FEBS Lett, 2007 Mar 6. PMID 17306798
    3. The structure of ADP-ribose pyrophosphatase reveals the structural basis for the versatility of the Nudix family. Gabelli SB, et al. Nat Struct Biol, 2001 May. PMID 11323725
    4. Mechanism of the Escherichia coli ADP-ribose pyrophosphatase, a Nudix hydrolase. Gabelli SB, et al. Biochemistry, 2002 Jul 30. PMID 12135348
    5. Nucleotide diphosphate hexose pyrophosphatases. Melo A, et al. Biochem Biophys Res Commun, 1966 Mar 8. PMID 5330035

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AspP binds to cell membranes as the bacterial population density increases.
      Title: Cytoplasmic Escherichia coli ADP sugar pyrophosphatase binds to cell membranes in response to extracellular signals as the cell population density increases.
    2. N-terminus verified by Edman degradation on complete protein
      Title: Interaction of purified NDH-1 from Escherichia coli with ubiquinone analogues.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ADP-ribose diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ADP-ribose diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ADP-sugar diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ADP-sugar diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyrophosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nucleoside phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribose phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ADP-sugar pyrophosphatase
    NP_417506.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3177281..3177910 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417506.1 ADP-sugar pyrophosphatase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417506.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1V2GHQ4, A0A376MIH0
      Conserved Domains (1) summary
      PRK10729
      Location:9 → 209
      nudF; ADP-ribose pyrophosphatase NudF; Provisional
    Nucleotide Protein
    Heading Accession and Version

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