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    tldD metalloprotease subunit TldD [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947749, updated on 3-Dec-2024

    Summary

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    Official Symbol
    tldD
    Official Full Name
    metalloprotease subunit TldD
    Primary source
    ECOCYC:G7689
    Locus tag
    b3244
    See related
    ASAP:ABE-0010642
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3233; yhdO
    Summary
    TldD and/or TldE act as a protease that is involved in sensitivity to DNA gyrase inhibitor LetD/CcdB (encoded by the F plasmid) by effecting degradation of the F plasmid-encoded LetD inhibitor, LetA/CcdA . [More information is available at EcoCyc: G7689].
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    Genomic context

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    Sequence:
    NC_000913.3 (3390583..3392028, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1656 domain-containing protein AaeX Neighboring gene DNA-binding transcriptional activator AaeR Neighboring gene phospholipid transport factor YhdP Neighboring gene RNase G Neighboring gene nucleoside triphosphate pyrophosphatase YhdE

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of pmbA, an Escherichia coli chromosomal gene required for the production of the antibiotic peptide MccB17. Rodríguez-Sáinz MC, et al. Mol Microbiol, 1990 Nov. PMID 2082149
    2. From the genome sequence to the proteome and back: evaluation of E. coli genome annotation with a 2-D gel-based proteomics approach. Maillet I, et al. Proteomics, 2007 Apr. PMID 17366475
    3. Proteome analysis of Escherichia coli using high-performance liquid chromatography and Fourier transform ion cyclotron resonance mass spectrometry. Ihling C, et al. Proteomics, 2005 May. PMID 15852340
    4. MEROPS: the peptidase database. Rawlings ND, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381862, Free PMC Article
    5. The Origins of Specificity in the Microcin-Processing Protease TldD/E. Ghilarov D, et al. Structure, 2017 Oct 3. PMID 28943336, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables iron ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of peptidase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    metalloprotease subunit TldD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3390583..3392028 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417711.1 metalloprotease subunit TldD [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417711.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7ECP2
      Conserved Domains (1) summary
      PRK10735
      Location:1 → 481
      tldD; protease TldD; Provisional
    Nucleotide Protein
    Heading Accession and Version

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