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    glgC glucose-1-phosphate adenylyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947942, updated on 3-Dec-2024

    Summary

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    Official Symbol
    glgC
    Official Full Name
    glucose-1-phosphate adenylyltransferase
    Primary source
    ECOCYC:EG10379
    Locus tag
    b3430
    See related
    ASAP:ABE-0011204
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3416
    Summary
    Glucose-1-phosphate adenylyltransferase catalyzes the rate-limiting first step in the biosynthesis of glycogen. [More information is available at EcoCyc: EG10379].
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    Genomic context

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    Sequence:
    NC_000913.3 (3568033..3569328, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene glycogen phosphorylase Neighboring gene glycogen synthase Neighboring gene limit dextrin alpha-1,6-glucohydrolase Neighboring gene 1,4-alpha-glucan branching enzyme Neighboring gene protein YhgO Neighboring gene protein YhgP

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and expression of the Escherichia coli glgC gene from a mutant containing an ADPglucose pyrophosphorylase with altered allosteric properties. Leung P, et al. J Bacteriol, 1986 Jul. PMID 3013841, Free PMC Article
    2. Aspartate residue 142 is important for catalysis by ADP-glucose pyrophosphorylase from Escherichia coli. Frueauf JB, et al. J Biol Chem, 2001 Dec 7. PMID 11567027
    3. Truncated forms of the recombinant Escherichia coli ADP-glucose pyrophosphorylase: the importance of the N-terminal region for allosteric activation and inhibition. Wu MX, et al. Arch Biochem Biophys, 2001 May 15. PMID 11339804
    4. The N-terminal region is important for the allosteric activation and inhibition of the Escherichia coli ADP-glucose pyrophosphorylase. Wu MX, et al. Arch Biochem Biophys, 1998 Oct 1. PMID 9750179
    5. A kinetic study of site-directed mutants of Escherichia coli ADP-glucose pyrophosphorylase: the role of residue 295 in allosteric regulation. Meyer CR, et al. Arch Biochem Biophys, 1998 Apr 15. PMID 9587413

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A model has been proposed in which the energy reporters regulate ADP-glucose pyrophosphorylase catalytic activity by intra-protomer interactions and inter-protomer crosstalk, with a sensory motif and two regulatory loops playing a prominent role.
      Title: Structural Basis of Glycogen Biosynthesis Regulation in Bacteria.
    2. Using computational studies, site-directed mutagenesis, and kinetic characterization, we found a critical region for transmitting the allosteric signal in the Escherichia coli ADP-glucose pyrophosphorylase
      Title: Conserved residues of the Pro103-Arg115 loop are involved in triggering the allosteric response of the Escherichia coli ADP-glucose pyrophosphorylase.
    3. ADP-glucose pyrophosphorylase with a pentapeptide insertion between Leu(102) and Pro(103) was catalytically competent but insensitive to activation.
      Title: Identification of regions critically affecting kinetics and allosteric regulation of the Escherichia coli ADP-glucose pyrophosphorylase by modeling and pentapeptide-scanning mutagenesis.
    4. N-terminus verified by Edman degradation on mature peptide
      Title: Biosynthesis of bacterial glycogen. Isolation and characterization of the pyridoxal-P allosteric activator site and the ADP-glucose-protected pyridoxal-P binding site of Escherichia coli B ADP-glucose synthase.
    5. Structural role of N-terminus in allosteric regulation of ADPglucose pyrophosphorylase was studied.
      Title: ADPglucose pyrophosphorylase's N-terminus: structural role in allosteric regulation.
    6. First detailed characterization of the sugar phosphate site and the three-dimensional structure of ADP-glucose pyrophosphorylase.
      Title: Molecular architecture of the glucose 1-phosphate site in ADP-glucose pyrophosphorylases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables AMP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucose-1-phosphate adenylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glucose-1-phosphate adenylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glycogen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of glucose-1-phosphate adenylyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glucose-1-phosphate adenylyltransferase
    NP_417888.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3568033..3569328 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417888.1 glucose-1-phosphate adenylyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417888.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9ACJ3, A0A8S7CKX0, A0A8T3UDF9
      Conserved Domains (1) summary
      PRK00725
      Location:5 → 429
      glgC; glucose-1-phosphate adenylyltransferase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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