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    livJ branched chain amino acid/phenylalanine ABC transporter periplasmic binding protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947971, updated on 17-Dec-2024

    Summary

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    Official Symbol
    livJ
    Official Full Name
    branched chain amino acid/phenylalanine ABC transporter periplasmic binding protein
    Primary source
    ECOCYC:EG10539
    Locus tag
    b3460
    See related
    ASAP:ABE-0011299
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3444; hrbB; hrbC; hrbD
    Summary
    After four hours of Zn(II) stress, LivJ protein levels decreased (Easton, 2006). [More information is available at EcoGene: EG10539]. LivFGHMJ and LivFGHMK are two ATP-dependent high-affinity branched-chain amino acid transport system and are members of the ATP Binding Cassette (ABC) Superfamily of transporters . [More information is available at EcoCyc: EG10539].
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    Genomic context

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    Sequence:
    NC_000913.3 (3598555..3599658, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene L-leucine/L-phenylalanine ABC transporter periplasmic binding protein Neighboring gene PanD maturation factor Neighboring gene RNA polymerase sigma factor RpoH Neighboring gene cell division protein FtsX Neighboring gene cell division protein FtsE

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Premature termination of in vivo transcription of a gene encoding a branched-chain amino acid transport protein in Escherichia coli. Williamson RM, et al. J Bacteriol, 1992 Mar. PMID 1372312, Free PMC Article
    2. A portion of the nucleotide sequence corresponding to the N-terminal coding region of livJ is essential for its transcriptional regulation. Matsubara K, et al. Biochim Biophys Acta, 2000 Nov 15. PMID 11072068
    3. Ligand-free and -bound structures of the binding protein (LivJ) of the Escherichia coli ABC leucine/isoleucine/valine transport system: trajectory and dynamics of the interdomain rotation and ligand specificity. Trakhanov S, et al. Biochemistry, 2005 May 3. PMID 15850393
    4. (19)F NMR studies of the leucine-isoleucine-valine binding protein: evidence that a closed conformation exists in solution. Salopek-Sondi B, et al. J Biomol Struct Dyn, 2003 Oct. PMID 12956607
    5. Crystal structure of AmiC: the controller of transcription antitermination in the amidase operon of Pseudomonas aeruginosa. Pearl L, et al. EMBO J, 1994 Dec 15. PMID 7813419, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: The gcvB gene encodes a small untranslated RNA involved in expression of the dipeptide and oligopeptide transport systems in Escherichia coli.
    2. Two different ligand-free structures of LivJ, combined with those of the very similar ligand-bound forms, indicate the trajectory and backbone torsion angle changes of the hinges that accompany domain closure and play crucial functional roles.
      Title: Ligand-free and -bound structures of the binding protein (LivJ) of the Escherichia coli ABC leucine/isoleucine/valine transport system: trajectory and dynamics of the interdomain rotation and ligand specificity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Process Evidence Code Pubs
    involved_in L-leucine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within L-leucine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within branched-chain amino acid transport EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in branched-chain amino acid transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in isoleucine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within isoleucine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in valine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within valine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in outer membrane-bounded periplasmic space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in outer membrane-bounded periplasmic space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    branched chain amino acid/phenylalanine ABC transporter periplasmic binding protein
    YP_026223.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3598555..3599658 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_026223.1 branched chain amino acid/phenylalanine ABC transporter periplasmic binding protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for YP_026223.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0E1LCW7, A0A7U9IVG5
      Conserved Domains (1) summary
      PRK15404
      Location:1 → 367
      PRK15404; high-affinity branched-chain amino acid ABC transporter substrate-binding protein
    Nucleotide Protein
    Heading Accession and Version

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