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    waaF ADP-heptose--LPS heptosyltransferase 2 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948135, updated on 3-Dec-2024

    Summary

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    Official Symbol
    waaF
    Official Full Name
    ADP-heptose--LPS heptosyltransferase 2
    Primary source
    ECOCYC:EG12210
    Locus tag
    b3620
    See related
    ASAP:ABE-0011845
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3610; rfaF
    Summary
    The lipopolysaccharide of Escherichia coli K-12 consists of two major components: the hydrophobic lipid A moiety inserted into the outer membrane and the phosphorylated core oligosaccharide . [More information is available at EcoCyc: EG12210].
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    Genomic context

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    Sequence:
    NC_000913.3 (3794929..3795975)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein HtrL Neighboring gene ADP-L-glycero-D-mannoheptose 6-epimerase Neighboring gene ADP-heptose:LPS heptosyltransferase 1 Neighboring gene O-antigen ligase Neighboring gene protein YibX;protein YibX-S

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kinetic Characterization and Computational Modeling of Escherichia coli Heptosyltransferase II: Exploring the Role of Protein Dynamics in Catalysis for GT-B Glycosyltransferase. Hassan BA, et al. Biochemistry, 2022 Aug 2. PMID 35861590
    2. Cloning, expression, and characterization of the Escherichia coli K-12 rfaD gene. Pegues JC, et al. J Bacteriol, 1990 Aug. PMID 2198271, Free PMC Article
    3. New cysE-pyrE-linked rfa mutation in Escherichia coli K-12 that results in a heptoseless lipopolysaccharide. Coleman WG Jr, et al. J Bacteriol, 1985 Mar. PMID 3882666, Free PMC Article
    4. Deletion of the heptosyltransferase genes rfaC and rfaF in Escherichia coli K-12 results in an Re-type lipopolysaccharide with a high degree of 2-aminoethanol phosphate substitution. Brabetz W, et al. Eur J Biochem, 1997 Jul 15. PMID 9266718
    5. Cloning and characterization of the Escherichia coli K-12 rfa-2 (rfaC) gene, a gene required for lipopolysaccharide inner core synthesis. Chen L, et al. J Bacteriol, 1993 May. PMID 8478319, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kinetic Characterization and Computational Modeling of Escherichia coli Heptosyltransferase II: Exploring the Role of Protein Dynamics in Catalysis for GT-B Glycosyltransferase.
      Title: Kinetic Characterization and Computational Modeling of Escherichia coli Heptosyltransferase II: Exploring the Role of Protein Dynamics in Catalysis for GT-B Glycosyltransferase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ADP-heptose-lipopolysaccharide heptosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ADP-heptose-lipopolysaccharide heptosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ADP-heptose-lipopolysaccharide heptosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipopolysaccharide core region biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipopolysaccharide core region biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipopolysaccharide core region biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ADP-heptose--LPS heptosyltransferase 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3794929..3795975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418077.1 ADP-heptose--LPS heptosyltransferase 2 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418077.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7EAG8
      Conserved Domains (1) summary
      PRK10916
      Location:1 → 348
      PRK10916; ADP-heptose--LPS heptosyltransferase RfaF
    Nucleotide Protein
    Heading Accession and Version

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