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    rlmB 23S rRNA 2'-O-ribose G2251 methyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948694, updated on 3-Dec-2024

    Summary

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    Official Symbol
    rlmB
    Official Full Name
    23S rRNA 2'-O-ribose G2251 methyltransferase
    Primary source
    ECOCYC:G7845
    Locus tag
    b4180
    See related
    ASAP:ABE-0013684
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4176; yjfH
    Summary
    rlmB is non-essential. [More information is available at EcoGene: EG12483]. RlmB is the methyltransferase responsible for methylation of 23S rRNA at the 2'-O position of the ribose at the G2251 nucleotide . [More information is available at EcoCyc: G7845].
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    Genomic context

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    Sequence:
    NC_000913.3 (4409275..4410006)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional regulator NsrR Neighboring gene RNase R Neighboring gene DUF2170 domain-containing protein YjfI Neighboring gene PspA family protein YjfJ

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the cofactor-binding site in the SPOUT-fold methyltransferases by computational docking of S-adenosylmethionine to three crystal structures. Kurowski MA, et al. BMC Bioinformatics, 2003 Mar 14. PMID 12689347, Free PMC Article
    2. Hybridization of antisense oligonucleotides with alpha-sarcin loop region of Escherichia coli 23S rRNA. Petyuk VA, et al. Nucleosides Nucleotides Nucleic Acids, 2004 Oct. PMID 15560079
    3. Cold shock induction of RNase R and its role in the maturation of the quality control mediator SsrA/tmRNA. Cairrão F, et al. Mol Microbiol, 2003 Nov. PMID 14622421
    4. The structure of the RlmB 23S rRNA methyltransferase reveals a new methyltransferase fold with a unique knot. Michel G, et al. Structure, 2002 Oct. PMID 12377117
    5. An indigenous posttranscriptional modification in the ribosomal peptidyl transferase center confers resistance to an array of protein synthesis inhibitors. Toh SM, et al. J Mol Biol, 2008 Jul 18. PMID 18554609, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables rRNA (guanosine-2'-O-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA (guanosine-2'-O-)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA (guanosine-2'-O-)-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA 2'-O-methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    23S rRNA 2'-O-ribose G2251 methyltransferase
    NP_418601.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4409275..4410006
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418601.1 23S rRNA 2'-O-ribose G2251 methyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418601.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AQP7
      Conserved Domains (1) summary
      PRK11181
      Location:1 → 243
      PRK11181; 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB
    Nucleotide Protein
    Heading Accession and Version

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