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    ulaR DNA-binding transcriptional repressor UlaR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948706, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ulaR
    Official Full Name
    DNA-binding transcriptional repressor UlaR
    Primary source
    ECOCYC:G7854
    Locus tag
    b4191
    See related
    ASAP:ABE-0013713
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4187; yjfQ
    Summary
    The ula divergon is comprised of the two divergent ulaGR and ulaABCDEF operons. [More information is available at EcoGene: EG12491]. UlaR is a DNA-binding transcription factor that is expressed constitutively and coordinately represses transcription of a divergent operon (ula) involved in transport and utilization of L-ascorbate catabolism . [More information is available at EcoCyc: G7854].
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    Genomic context

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    Sequence:
    NC_000913.3 (4417698..4418453, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene protease activator YjfN Neighboring gene DUF1471 domain-containing putative lipoprotein BsmA Neighboring gene carboxylesterase Neighboring gene L-ascorbate-6-phosphate lactonase Neighboring gene L-ascorbate specific PTS enzyme IIC component

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Diversification of catalytic activities and ligand interactions in the protein fold shared by the sugar isomerases, eIF2B, DeoR transcription factors, acyl-CoA transferases and methenyltetrahydrofolate synthetase. Anantharaman V, et al. J Mol Biol, 2006 Feb 24. PMID 16376935
    2. Quaternary structural transitions in the DeoR-type repressor UlaR control transcriptional readout from the L-ascorbate utilization regulon in Escherichia coli. Garces F, et al. Biochemistry, 2008 Nov 4. PMID 18844374
    3. Gene regulation at-a-distance in E. coli: new insights. Amouyal M. C R Biol, 2005 Jan. PMID 15714875
    4. Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals. Huerta AM, et al. J Mol Biol, 2003 Oct 17. PMID 14529615
    5. Bioinformatic analyses of the bacterial L-ascorbate phosphotransferase system permease family. Hvorup R, et al. J Mol Microbiol Biotechnol, 2003. PMID 15153772

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. identified the key amino acid residues that mediate L-ascorbate 6-phosphate binding and constructed the first model of regulation of a DeoR family member, establishing the basis of the ula regulon transcription control by UlaR
      Title: Quaternary structural transitions in the DeoR-type repressor UlaR control transcriptional readout from the L-ascorbate utilization regulon in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-ascorbic acid binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ligand-activated transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional repressor UlaR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4417698..4418453 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418612.1 DNA-binding transcriptional repressor UlaR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418612.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A828P3Q3
      Conserved Domains (1) summary
      PRK13509
      Location:1 → 251
      PRK13509; HTH-type transcriptional regulator UlaR
    Nucleotide Protein
    Heading Accession and Version

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