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    nadC quinolinate phosphoribosyltransferase (decarboxylating) [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948869, updated on 3-Dec-2024

    Summary

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    Official Symbol
    nadC
    Official Full Name
    quinolinate phosphoribosyltransferase (decarboxylating)
    Primary source
    ECOCYC:EG11546
    Locus tag
    b0109
    See related
    ASAP:ABE-0000374
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0108
    Summary
    Quinolinate phosphoribosyltransferase (NadC) catalyzes the third step in the de novo biosynthesis of NAD from L-aspartate . nadC mutants excrete quinolinate . [More information is available at EcoCyc: EG11546].
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    Genomic context

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    Sequence:
    NC_000913.3 (117752..118645, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene inner membrane protein HofC Neighboring gene T2SSE family protein Neighboring gene prepilin-type N-terminal cleavage/methylation domain-containing protein PpdD Neighboring gene 1,6-anhydro-N-acetylmuramoyl-L-alanine amidase Neighboring gene protein AmpE Neighboring gene aromatic amino acid:H(+) symporter AroP

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Paraquat toxicity and pyridine nucleotide coenzyme synthesis: a data correction. Brown OR, et al. Free Radic Biol Med, 1990. PMID 2139629
    2. Lys70 of E. coli quinolinate phosphoribosyltransferase is protected from chemical modification by formation of an inhibitor complex. Gaur R, et al. Protein Pept Lett, 2006. PMID 16472078
    3. Quinolinate phosphoribosyl transferase is not the oxygen-sensitive site of nicotinamide adenine dinucleotide biosynthesis. Gardner PR, et al. Free Radic Biol Med, 1990. PMID 2139630
    4. The sequencing expression, purification, and steady-state kinetic analysis of quinolinate phosphoribosyl transferase from Escherichia coli. Bhatia R, et al. Arch Biochem Biophys, 1996 Jan 15. PMID 8561507
    5. Chromosomal location of the C gene involved in the biosynthesis of nicotinamide adenine dinucleotide in Escherichia coli K-12. Tritz GJ, et al. J Bacteriol, 1970 Oct. PMID 4319723, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nicotinate-nucleotide diphosphorylase (carboxylating) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nicotinate-nucleotide diphosphorylase (carboxylating) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nicotinate-nucleotide diphosphorylase (carboxylating) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within 'de novo' NAD biosynthetic process from aspartate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in NAD biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within NAD biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyridine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in quinolinate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    quinolinate phosphoribosyltransferase (decarboxylating)
    NP_414651.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      117752..118645 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414651.1 quinolinate phosphoribosyltransferase (decarboxylating) [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414651.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8H9VQB6
      Conserved Domains (1) summary
      PRK09016
      Location:1 → 297
      PRK09016; carboxylating nicotinate-nucleotide diphosphorylase
    Nucleotide Protein
    Heading Accession and Version

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