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    proB glutamate 5-kinase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946425, updated on 17-Dec-2024

    Summary

    Official Symbol
    proB
    Official Full Name
    glutamate 5-kinase
    Primary source
    ECOCYC:EG10768
    Locus tag
    b0242
    See related
    ASAP:ABE-0000830
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0243; pro(2); pro2
    Summary
    Contains PUA domain, required for proline-triggered aggregation. [More information is available at EcoGene: EG10768].
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    Genomic context

    Sequence:
    NC_000913.3 (260388..261491)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene IS1 family transposase B Neighboring gene pseudo Neighboring gene IS1 family repressor TnpA Neighboring gene outer membrane porin PhoE Neighboring gene glutamate-5-semialdehyde dehydrogenase Neighboring gene tRNA-Thr

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables glutamate 5-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glutamate 5-kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glutamate 5-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables proline binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in L-proline biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within L-proline biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proline biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proline biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within proline biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    glutamate 5-kinase
    NP_414777.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      260388..261491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414777.1 glutamate 5-kinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414777.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A192CI68, A0AA36KUS5
      Conserved Domains (1) summary
      PRK05429
      Location:1365
      PRK05429; gamma-glutamyl kinase; Provisional