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    betT choline:H(+) symporter [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945079, updated on 17-Dec-2024

    Summary

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    Official Symbol
    betT
    Official Full Name
    choline:H(+) symporter
    Primary source
    ECOCYC:EG10112
    Locus tag
    b0314
    See related
    ASAP:ABE-0001080
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0312
    Summary
    The bet genes are induced by choline, oxygen, and osmotic stress. [More information is available at EcoGene: EG10112]. BetT is a proton-motive-force-driven choline transporter that belongs to the Betaine Carnitine Choline Transport (BCCT) family of proteins. [More information is available at EcoCyc: EG10112].
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    Genomic context

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    Sequence:
    NC_000913.3 (329463..331496)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene betaine aldehyde dehydrogenase Neighboring gene DNA-binding transcriptional repressor BetI Neighboring gene protein YahV Neighboring gene DNA-binding transcriptional regulator/c-di-GMP phosphodiesterase PdeL

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. lac fusion analysis of the bet genes of Escherichia coli: regulation by osmolarity, temperature, oxygen, choline, and glycine betaine. Eshoo MW. J Bacteriol, 1988 Nov. PMID 3141381, Free PMC Article
    2. DNA-binding properties of the BetI repressor protein of Escherichia coli: the inducer choline stimulates BetI-DNA complex formation. Rkenes TP, et al. J Bacteriol, 1996 Mar. PMID 8626295, Free PMC Article
    3. The complex bet promoters of Escherichia coli: regulation by oxygen (ArcA), choline (BetI), and osmotic stress. Lamark T, et al. J Bacteriol, 1996 Mar. PMID 8626294, Free PMC Article
    4. DNA sequence and analysis of the bet genes encoding the osmoregulatory choline-glycine betaine pathway of Escherichia coli. Lamark T, et al. Mol Microbiol, 1991 May. PMID 1956285
    5. Membrane topology and mutational analysis of the osmotically activated BetT choline transporter of Escherichia coli. Tøndervik A, et al. Microbiology (Reading), 2007 Mar. PMID 17322201

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables choline transmembrane transporter activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within choline transport EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in glycine betaine biosynthetic process from choline IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    choline:H(+) symporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      329463..331496
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414848.1 choline:H(+) symporter [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414848.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7TU02
      Conserved Domains (1) summary
      PRK09928
      Location:1 → 677
      PRK09928; choline transport protein BetT; Provisional
    Nucleotide Protein
    Heading Accession and Version

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