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    mhpB 3-carboxyethylcatechol 2,3-dioxygenase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945047, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mhpB
    Official Full Name
    3-carboxyethylcatechol 2,3-dioxygenase
    Primary source
    ECOCYC:M011
    Locus tag
    b0348
    See related
    ASAP:ABE-0001198
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0345
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    Genomic context

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    Sequence:
    NC_000913.3 (370277..371221)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional activator MhpR Neighboring gene 3-(3-hydroxyphenyl)propanoate hydroxylase Neighboring gene 2-hydroxy-6-ketonona-2,4-dienedioate hydrolase Neighboring gene 2-hydroxypentadienoate hydratase Neighboring gene acetaldehyde dehydrogenase (acetylating) MhpF

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence from mechanistic probes for distinct hydroperoxide rearrangement mechanisms in the intradiol and extradiol catechol dioxygenases. Xin M, et al. J Am Chem Soc, 2008 Aug 6. PMID 18627158
    2. Directed evolution of a non-heme-iron-dependent extradiol catechol dioxygenase: identification of mutants with intradiol oxidative cleavage activity. Schlosrich J, et al. Chembiochem, 2006 Dec. PMID 17051653
    3. Catechol dioxygenases from Escherichia coli (MhpB) and Alcaligenes eutrophus (MpcI): sequence analysis and biochemical properties of a third family of extradiol dioxygenases. Spence EL, et al. J Bacteriol, 1996 Sep. PMID 8752345, Free PMC Article
    4. Overproduction, purification and properties of 2,3-dihydroxyphenylpropionate 1,2-dioxygenase from Escherichia coli. Bugg TD. Biochim Biophys Acta, 1993 Oct 6. PMID 8399388
    5. Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli. Burlingame R, et al. J Bacteriol, 1983 Jul. PMID 6345502, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Overproduction, purification and properties of 2,3-dihydroxyphenylpropionate 1,2-dioxygenase from Escherichia coli.
    2. A catalytic mechanism involving His-179 and His-115 as acid-base catalytic residues is proposed for MhpB.
      Title: Acid-base catalysis in the extradiol catechol dioxygenase reaction mechanism: site-directed mutagenesis of His-115 and His-179 in Escherichia coli 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB).
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3-carboxyethylcatechol 2,3-dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-carboxyethylcatechol 2,3-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferrous iron binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ferrous iron binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within 3-(3-hydroxy)phenylpropionate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in 3-phenylpropionate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phenylpropanoid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    3-carboxyethylcatechol 2,3-dioxygenase
    NP_414882.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      370277..371221
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414882.1 3-carboxyethylcatechol 2,3-dioxygenase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414882.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1N1R3, A0A6C9QBU9, A0A8S7EJ18
      Conserved Domains (1) summary
      cd07365
      Location:1 → 311
      MhpB_like; Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate
    Nucleotide Protein
    Heading Accession and Version

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