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    frmB S-formylglutathione hydrolase FrmB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944991, updated on 3-Dec-2024

    Summary

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    Official Symbol
    frmB
    Official Full Name
    S-formylglutathione hydrolase FrmB
    Primary source
    ECOCYC:G6208
    Locus tag
    b0355
    See related
    ASAP:ABE-0001219
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0352; yaiM
    Summary
    FrmB also has p-nitrophenyl C2-C6 fatty acid ester and a-naphthyl acetate carboxylesterase activities in vitro. [More information is available at EcoGene: EG13295]. FrmB is a promiscuous serine hydrolase; its highest specific activity is with the substrate S-formylglutathione. [More information is available at EcoCyc: G6208].
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    Genomic context

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    Sequence:
    NC_000913.3 (377535..378368, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 3-hydroxyphenylpropionate/3-hydroxycinnamate:H(+) symporter Neighboring gene DUF2058 domain-containing protein YaiL Neighboring gene S-(hydroxymethyl)glutathione dehydrogenase Neighboring gene DNA-binding transcriptional repressor FrmR

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular basis of formaldehyde detoxification. Characterization of two S-formylglutathione hydrolases from Escherichia coli, FrmB and YeiG. Gonzalez CF, et al. J Biol Chem, 2006 May 19. PMID 16567800
    2. The response of Escherichia coli to exposure to the biocide polyhexamethylene biguanide. Allen MJ, et al. Microbiology (Reading), 2006 Apr. PMID 16549663
    3. Global transcriptional effects of a suppressor tRNA and the inactivation of the regulator frmR. Herring CD, et al. J Bacteriol, 2004 Oct. PMID 15466022, Free PMC Article
    4. MEROPS: the peptidase database. Rawlings ND, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381862, Free PMC Article
    5. S-formylglutathione hydrolase of Paracoccus denitrificans is homologous to human esterase D: a universal pathway for formaldehyde detoxification? Harms N, et al. J Bacteriol, 1996 Nov. PMID 8892832, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. and YeiG are S-formylglutathione hydrolases with a Ser-His-Asp catalytic triad involved in the detoxification of formaldehyde in E. coli
      Title: Molecular basis of formaldehyde detoxification. Characterization of two S-formylglutathione hydrolases from Escherichia coli, FrmB and YeiG.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables S-formylglutathione hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables S-formylglutathione hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables S-formylglutathione hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in formaldehyde catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within formaldehyde metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    S-formylglutathione hydrolase FrmB
    NP_414889.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      377535..378368 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414889.1 S-formylglutathione hydrolase FrmB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414889.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6C9QC98
      Conserved Domains (1) summary
      cl21494
      Location:2 → 274
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version

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