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    frmR DNA-binding transcriptional repressor FrmR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944986, updated on 3-Dec-2024

    Summary

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    Official Symbol
    frmR
    Official Full Name
    DNA-binding transcriptional repressor FrmR
    Primary source
    ECOCYC:G6209
    Locus tag
    b0357
    See related
    ASAP:ABE-0001226
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0354; yaiN
    Summary
    The frmRAB operon is negatively regulated by frmR, is induced by formaldehyde, and probably degrades formaldehyde. [More information is available at EcoGene: EG13296]. FrmR appears to be a negative regulator of the frmRAB operon; its function can be inactivated by suppression of its amber stop codon . frmR expression is induced by formaldehyde, but not by S-nitrosoglutathione . [More information is available at EcoCyc: G6209].
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    Genomic context

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    Sequence:
    NC_000913.3 (379606..379881, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene S-formylglutathione hydrolase FrmB Neighboring gene S-(hydroxymethyl)glutathione dehydrogenase Neighboring gene outer membrane protein YaiO Neighboring gene pseudo Neighboring gene IS2 element protein InsA Neighboring gene IS2 element protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mechanism of a formaldehyde-sensing transcriptional regulator. Denby KJ, et al. Sci Rep, 2016 Dec 9. PMID 27934966, Free PMC Article
    2. The response of Escherichia coli to exposure to the biocide polyhexamethylene biguanide. Allen MJ, et al. Microbiology (Reading), 2006 Apr. PMID 16549663
    3. Global transcriptional effects of a suppressor tRNA and the inactivation of the regulator frmR. Herring CD, et al. J Bacteriol, 2004 Oct. PMID 15466022, Free PMC Article
    4. A functional update of the Escherichia coli K-12 genome. Serres MH, et al. Genome Biol, 2001. PMID 11574054, Free PMC Article
    5. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription repressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-DNA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional repressor FrmR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      379606..379881 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414891.4 DNA-binding transcriptional repressor FrmR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414891.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A785IT28
      Conserved Domains (1) summary
      PRK11352
      Location:1 → 91
      PRK11352; formaldehyde-responsive transcriptional repressor FrmR
    Nucleotide Protein
    Heading Accession and Version

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