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    acpH acyl carrier protein phosphodiesterase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 949132, updated on 3-Dec-2024

    Summary

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    Official Symbol
    acpH
    Official Full Name
    acyl carrier protein phosphodiesterase
    Primary source
    ECOCYC:EG11095
    Locus tag
    b0404
    See related
    ASAP:ABE-0001404
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0398; yajB
    Summary
    AcpH is required for turnover of the acyl carrier protein (ACP) prosthetic group 4'-phosphopanthetheine at Ser36 in vivo. [More information is available at EcoGene: EG11095]. Acyl carrier protein (ACP) phosphodiesterase is responsible for the cleavage of |FRAME: [More information is available at EcoCyc: EG11095].
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    Genomic context

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    Sequence:
    NC_000913.3 (424337..424918, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transporter ProY Neighboring gene maltodextrin glucosidase Neighboring gene tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase Neighboring gene tRNA-guanine transglycosylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Acyl carrier protein. IX. Acyl carrier protein hydrolase. Vagelos PR, et al. J Biol Chem, 1967 Apr 25. PMID 4290442
    2. Acyl carrier protein phosphodiesterase (AcpH) of Escherichia coli is a non-canonical member of the HD phosphatase/phosphodiesterase family. Thomas J, et al. Biochemistry, 2007 Jan 9. PMID 17198382
    3. The promoter of the tgt/sec operon in Escherichia coli is preceded by an upstream activation sequence that contains a high affinity FIS binding site. Slany RK, et al. Nucleic Acids Res, 1992 Aug 25. PMID 1508713, Free PMC Article
    4. Structure and organization of Escherichia coli genes involved in biosynthesis of the deazaguanine derivative queuine, a nutrient factor for eukaryotes. Reuter K, et al. J Bacteriol, 1991 Apr. PMID 1706703, Free PMC Article
    5. Global analysis of candidate genes important for fitness in a competitive biofilm using DNA-array-based transposon mapping. Junker LM, et al. Microbiology (Reading), 2006 Aug. PMID 16849790

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ACP hydrolyase, also called ACP phosphodiesterase, is encoded by a gene (yajB) that has been renamed acpH
      Title: The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: genetic and enzymological characterization.
    2. Acyl carrier protein phosphodiesterase is a member of the HD protein family despite the lack of the signature histidine residue.
      Title: Acyl carrier protein phosphodiesterase (AcpH) of Escherichia coli is a non-canonical member of the HD phosphatase/phosphodiesterase family.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables [acyl-carrier-protein] phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables [acyl-carrier-protein] phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables [acyl-carrier-protein] phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    acyl carrier protein phosphodiesterase
    NP_414938.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      424337..424918 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414938.1 acyl carrier protein phosphodiesterase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414938.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T6BBK8
      Conserved Domains (1) summary
      PRK10045
      Location:1 → 193
      PRK10045; ACP phosphodiesterase
    Nucleotide Protein
    Heading Accession and Version

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