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    queA tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944905, updated on 17-Dec-2024

    Summary

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    Official Symbol
    queA
    Official Full Name
    tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase
    Primary source
    ECOCYC:EG10812
    Locus tag
    b0405
    See related
    ASAP:ABE-0001411
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0399; tsaA
    Summary
    Asn, Asp, Tyr, and His tRNA anticodons are modified. [More information is available at EcoGene: EG10812]. The queA gene encodes an S-adenosylmethionine:tRNA ribosyltransferase-isomerase, which catalyzes formation of the 2,3-epoxy-4,5-dihydroxycyclopentane ring of epoxyqueuosine (oQ), a precursor of the queuosine (Q) anticodon loop modification in tRNA(Asp), tRNA(Asn), tRNA(His), and tRNA(Tyr) . [More information is available at EcoCyc: EG10812].
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    Genomic context

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    Sequence:
    NC_000913.3 (425011..426081)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene maltodextrin glucosidase Neighboring gene acyl carrier protein phosphodiesterase Neighboring gene tRNA-guanine transglycosylase Neighboring gene Sec translocon accessory complex subunit YajC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure determination of a nucleoside Q precursor isolated from E. coli tRNA: 7-(aminomethyl)-7-deazaguanosine. Okada N, et al. Nucleic Acids Res, 1978 Jul. PMID 353740, Free PMC Article
    2. Isolation and structure elucidation of an epoxide derivative of the hypermodified nucleoside queuosine from Escherichia coli transfer RNA. Phillipson DW, et al. J Biol Chem, 1987 Mar 15. PMID 3102486
    3. New function of vitamin B12: cobamide-dependent reduction of epoxyqueuosine to queuosine in tRNAs of Escherichia coli and Salmonella typhimurium. Frey B, et al. J Bacteriol, 1988 May. PMID 3129401, Free PMC Article
    4. Screening orthologs as an important variable in crystallization: preliminary X-ray diffraction studies of the tRNA-modifying enzyme S-adenosyl-methionine:tRNA ribosyl transferase/isomerase. Grimm C, et al. Acta Crystallogr D Biol Crystallogr, 2000 Apr. PMID 10739928
    5. Mechanistic studies of the tRNA-modifying enzyme QueA: a chemical imperative for the use of AdoMet as a "ribosyl" donor. Kinzie SD, et al. Org Lett, 2000 May 4. PMID 10810734

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in queuosine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in queuosine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within queuosine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble guanine modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within tRNA wobble guanine modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase
    NP_414939.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      425011..426081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414939.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414939.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A377DWE9
      Conserved Domains (1) summary
      PRK00147
      Location:1 → 344
      queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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