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    yajL protein/nucleic acid deglycase 3 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945066, updated on 3-Dec-2024

    Summary

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    Official Symbol
    yajL
    Official Full Name
    protein/nucleic acid deglycase 3
    Primary source
    ECOCYC:G198
    Locus tag
    b0424
    See related
    ASAP:ABE-0001472
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0418; thiJ
    Summary
    YajL has been mistakenly described as ThiJ, involved in thiamine metabolism. [More information is available at EcoGene: EG13272]. YajL was mistakenly identified as ThiJ and was implicated in thiamine biosynthesis. [More information is available at EcoCyc: G198].
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    Genomic context

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    Sequence:
    NC_000913.3 (443051..443641, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene geranyl diphosphate/farnesyl diphosphate synthase Neighboring gene exodeoxyribonuclease VII subunit XseB Neighboring gene tRNA uridine 4-sulfurtransferase Neighboring gene 2-dehydropantoate 2-reductase Neighboring gene nucleotide binding protein YajQ Neighboring gene putative transport protein YajR

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Global stress response in a prokaryotic model of DJ-1-associated Parkinsonism. Messaoudi N, et al. J Bacteriol, 2013 Mar. PMID 23292772, Free PMC Article
    2. Translational defects in a mutant deficient in YajL, the bacterial homolog of the parkinsonism-associated protein DJ-1. Kthiri F, et al. J Bacteriol, 2010 Dec. PMID 20889753, Free PMC Article
    3. Protein aggregation in a mutant deficient in yajL, the bacterial homolog of the Parkinsonism-associated protein DJ-1. Kthiri F, et al. J Biol Chem, 2010 Apr 2. PMID 20124404, Free PMC Article
    4. Purification and properties of hydroxymethylpyrimidine kinase from Escherichia coli. Mizote T, et al. Biochim Biophys Acta, 1989 Apr 25. PMID 2540841
    5. Identification of a gene involved in the generation of 4-thiouridine in tRNA. Mueller EG, et al. Nucleic Acids Res, 1998 Jun 1. PMID 9592144, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Parkinsonism-associated protein DJ-1 and its bacterial homologs deglycase 1/Hsp31, deglycase 2/YhbO, and deglycase 3/YajL function as deglycases that repair proteins and nucleotides from endogeneous glycation by glyoxal and methylglyoxal. DJ-1, deglycase 1 and deglycase 2 repair glyoxal- and methylglyoxal-glycated substrates, whereas deglycase 3 principally repairs glyoxal-glycated substrates.
      Title: Further characterization of the Maillard deglycase DJ-1 and its prokaryotic homologs, deglycase 1/Hsp31, deglycase 2/YhbO, and deglycase 3/YajL.
    2. Purified YajL, YhbO and ElbB exhibited glyoxalase activity with different substrate specificities, optimal pHs and metal effects.
      Title: Characterization of the Escherichia coli YajL, YhbO and ElbB glyoxalases.
    3. Moreover, yhbO and yajL mutants display decreased viability in methylglyoxal- or glucose-containing media
      Title: The DJ-1 superfamily members YhbO and YajL from Escherichia coli repair proteins from glycation by methylglyoxal and glyoxal.
    4. protein defects resulting from the yajL mutation trigger the onset of a robust and global stress response in a prokaryotic model of DJ-1-associated Parkinsonism.
      Title: Global stress response in a prokaryotic model of DJ-1-associated Parkinsonism.
    5. YajL and possibly DJ-1 function as covalent chaperones involved in the detection of sulfenylated proteins by forming mixed disulfides with them and that these disulfides are subsequently reduced by low-molecular-weight thiols.
      Title: YajL, the prokaryotic homolog of the Parkinsonism-associated protein DJ-1, protects cells against protein sulfenylation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein deglycase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein deglycase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein refolding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein refolding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein refolding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in thiamine biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein/nucleic acid deglycase 3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      443051..443641 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414958.4 protein/nucleic acid deglycase 3 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414958.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1X3JM25
      Conserved Domains (1) summary
      PRK11574
      Location:1 → 196
      PRK11574; protein deglycase YajL
    Nucleotide Protein
    Heading Accession and Version

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