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    fsaA fructose-6-phosphate aldolase 1 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945449, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fsaA
    Official Full Name
    fructose-6-phosphate aldolase 1
    Primary source
    ECOCYC:G6428
    Locus tag
    b0825
    See related
    ASAP:ABE-0002818
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0815; fsa; mipB; ybiZ
    Summary
    The enzyme is made up of either 10 or 12 subunits. [More information is available at EcoCyc: G6428].
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    Genomic context

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    Sequence:
    NC_000913.3 (863642..864304)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative pyruvate formate lyase Neighboring gene putative pyruvate formate-lyase activating enzyme YbiY Neighboring gene molybdopterin-synthase adenylyltransferase Neighboring gene molybdopterin molybdotransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Opening a Novel Biosynthetic Pathway to Dihydroxyacetone and Glycerol in Escherichia coli Mutants through Expression of a Gene Variant (fsaA(A129S)) for Fructose 6-Phosphate Aldolase. Guitart Font E, et al. Int J Mol Sci, 2020 Dec 17. PMID 33348713, Free PMC Article
    2. Asymmetric self- and cross-aldol reactions of glycolaldehyde catalyzed by D-fructose-6-phosphate aldolase. Garrabou X, et al. Angew Chem Int Ed Engl, 2009. PMID 19554584
    3. D-fructose-6-phosphate aldolase in organic synthesis: cascade chemical-enzymatic preparation of sugar-related polyhydroxylated compounds. Concia AL, et al. Chemistry, 2009. PMID 19222084
    4. D-Fructose-6-phosphate aldolase-catalyzed one-pot synthesis of iminocyclitols. Sugiyama M, et al. J Am Chem Soc, 2007 Nov 28. PMID 17985886
    5. Fructose-6-phosphate aldolase in organic synthesis: preparation of D-fagomine, N-alkylated derivatives, and preliminary biological assays. Castillo JA, et al. Org Lett, 2006 Dec 21. PMID 17165931

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Opening a Novel Biosynthetic Pathway to Dihydroxyacetone and Glycerol in Escherichia coli Mutants through Expression of a Gene Variant (fsaA(A129S)) for Fructose 6-Phosphate Aldolase.
      Title: Opening a Novel Biosynthetic Pathway to Dihydroxyacetone and Glycerol in Escherichia coli Mutants through Expression of a Gene Variant (fsaA(A129S)) for Fructose 6-Phosphate Aldolase.
    2. N-terminus verified by Edman degradation on mature peptide
      Title: Fructose-6-phosphate aldolase is a novel class I aldolase from Escherichia coli and is related to a novel group of bacterial transaldolases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables aldehyde-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fructose 6-phosphate aldolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fructose 6-phosphate aldolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fructose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ketone catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fructose-6-phosphate aldolase 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      863642..864304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415346.4 fructose-6-phosphate aldolase 1 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415346.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376FS00, A0A6N8ND32
      Conserved Domains (1) summary
      PRK12653
      Location:1 → 220
      PRK12653; fructose-6-phosphate aldolase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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