iaaA isoaspartyl dipeptidase proenzyme [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: iaaA
Official Full Name: isoaspartyl dipeptidase proenzyme
Primary source: ECOCYC:EG12407
Locus tag: b0828
See related: ASAP:ABE-0002828
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK0818; spt; ybiK
Summary: IaaA is cleaved before Thr179 to expose N-terminal nucleophile and to produce two subunits. [More information is available at EcoGene: EG12407]. Asparaginase III is first synthesized as a proenzyme which is autocatalytically cleaved post-translationally into two smaller polypeptides. [More information is available at EcoCyc: EG12407].
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NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

results show that residues 195RKH197 of E. coli L-ASP are critical to its antigenicity
Title: Probing the antigenicity of E. coli L-asparaginase by mutational analysis.
analysis of allosteric regulation of the cytoplasmic Escherichia coli L-asparaginase I
Title: Crystal structure and allosteric regulation of the cytoplasmic Escherichia coli L-asparaginase I.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables asparaginase activity	IBA Inferred from Biological aspect of Ancestor more info
enables asparaginase activity	IDA Inferred from Direct Assay more info	PubMed
enables beta-aspartyl-peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-aspartyl-peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables beta-aspartyl-peptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein autoprocessing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

NP_415349.1

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The following sections contain reference sequences that belong to a specific genome build. Explain