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    matP macrodomain Ter protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945570, updated on 3-Dec-2024

    Summary

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    Official Symbol
    matP
    Official Full Name
    macrodomain Ter protein
    Primary source
    ECOCYC:EG12855
    Locus tag
    b0956
    See related
    ASAP:ABE-0003238
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0947; ycbG
    Summary
    MatP: [More information is available at EcoCyc: EG12855].
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    Genomic context

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    Sequence:
    NC_000913.3 (1018485..1018937)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene beta-hydroxyacyl-acyl carrier protein dehydratase/isomerase Neighboring gene putative ATP-dependent protease YcbZ Neighboring gene outer membrane protein A Neighboring gene cell division inhibitor SulA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Competitive binding of MatP and topoisomerase IV to the MukB hinge domain. Fisher GL, et al. Elife, 2021 Sep 29. PMID 34585666, Free PMC Article
    2. [Removable partial dentures and masticatory functions of mandibular resection patients]. Koshino H, et al. Higashi Nihon Shigaku Zasshi, 1988 Dec. PMID 3273290
    3. The MatP/matS site-specific system organizes the terminus region of the E. coli chromosome into a macrodomain. Mercier R, et al. Cell, 2008 Oct 31. PMID 18984159
    4. [Bacterial chromosome organization]. Mercier R, et al. Med Sci (Paris), 2009 Nov. PMID 19951655
    5. Expression, purification and preliminary structural analysis of Escherichia coli MatP in complex with the matS DNA site. Durand D, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012 Jun 1. PMID 22684059, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interpretation of organizational role of proteins on E. coli nucleoid via Hi-C integrated model.
      Title: Interpretation of organizational role of proteins on E. coli nucleoid via Hi-C integrated model.
    2. Competitive binding of MatP and topoisomerase IV to the MukB hinge domain.
      Title: Competitive binding of MatP and topoisomerase IV to the MukB hinge domain.
    3. Post-replicative pairing of sister ter regions in Escherichia coli involves multiple activities of MatP.
      Title: Post-replicative pairing of sister ter regions in Escherichia coli involves multiple activities of MatP.
    4. MatP can interact with lipid membranes reproducing the phospholipid mixture in the E. coli inner membrane.
      Title: The Bacterial DNA Binding Protein MatP Involved in Linking the Nucleoid Terminal Domain to the Divisome at Midcell Interacts with Lipid Membranes.
    5. This interaction is modulated by MatP, a protein involved in the organization of the Ter macrodomain. These results show that Topo IV, XerCD/dif and MatP are part of a network dedicated to the final step of chromosome management during the cell cycle.
      Title: Mapping Topoisomerase IV Binding and Activity Sites on the E. coli Genome.
    6. Data show that the replication terminus attaches to the divisome in a single segment along the perimeter of the cell in a MatP, ZapA and ZapB proteins-dependent manner.
      Title: The role of MatP, ZapA and ZapB in chromosomal organization and dynamics in Escherichia coli.
    7. Impairing the TopoIV-MukBEF interaction delays sister ter segregation in cells lacking MatP.
      Title: MatP regulates the coordinated action of topoisomerase IV and MukBEF in chromosome segregation.
    8. studies revealing the molecular basis for Terminus-containing (Ter) chromosome condensation by the Ter-specific factor MatP
      Title: Molecular basis for a protein-mediated DNA-bridging mechanism that functions in condensation of the E. coli chromosome.
    9. demonstrated that MatP forms dimers that bind a single matS motif
      Title: Expression, purification and preliminary structural analysis of Escherichia coli MatP in complex with the matS DNA site.
    10. The effects of MatP inactivation reveal its role as main organizer of the Ter macrodomain: in the absence of MatP (ycbG), DNA is less compacted, the mobility of markers is increased, and segregation of Ter macrodomain occurs early in the cell cycle.
      Title: The MatP/matS site-specific system organizes the terminus region of the E. coli chromosome into a macrodomain.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chromosome organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in DNA replication termination region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    macrodomain Ter protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1018485..1018937
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415476.1 macrodomain Ter protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415476.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376UCI0, A0A8H9T4U5
      Conserved Domains (1) summary
      PRK05097
      Location:1 → 150
      PRK05097; macrodomain Ter protein MatP
    Nucleotide Protein
    Heading Accession and Version

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