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    fabD [acyl-carrier-protein] S-malonyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945766, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fabD
    Official Full Name
    [acyl-carrier-protein] S-malonyltransferase
    Primary source
    ECOCYC:EG11317
    Locus tag
    b1092
    See related
    ASAP:ABE-0003698
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1078; tfpA
    Summary
    The fabD gene is part of a fatty acid biosynthesis operon and the malonyl-CoA transacylase is part of a multienzyme fatty acid synthase II complex. [More information is available at EcoCyc: EG11317].
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    Genomic context

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    Sequence:
    NC_000913.3 (1149728..1150657)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative phosphate acyltransferase Neighboring gene 3-oxoacyl-[acyl carrier protein] synthase 3 Neighboring gene 3-oxoacyl-[acyl-carrier-protein] reductase FabG Neighboring gene acyl carrier protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutants of Escherichia coli with temperature-sensitive malonyl coenzyme A-acyl carrier protein transacylase. Harder ME, et al. J Biol Chem, 1974 Dec 10. PMID 4612036
    2. Studies on the mechanism of fatty acid synthesis. XXVI. Purification and properties of malonyl-coenzyme A--acyl carrier protein transacylase of Escherichia coli. Joshi VC, et al. Arch Biochem Biophys, 1971 Apr. PMID 4934182
    3. Resistance to trifluoroperazine, a calmodulin inhibitor, maps to the fabD locus in Escherichia coli. Bouquin N, et al. Mol Gen Genet, 1995 Mar 10. PMID 7700236
    4. Characterization of a malonyl-enzyme intermediate and identification of the malonyl binding site in malonyl coenzyme A-acyl carrier protein transacylase of Escherichia coli. Ruch FE, et al. J Biol Chem, 1973 Dec 10. PMID 4584823
    5. Molecular characterization of an Escherichia coli mutant with a temperature-sensitive malonyl coenzyme A-acyl carrier protein transacylase. Verwoert II, et al. FEBS Lett, 1994 Jul 18. PMID 8034061

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interfacial plasticity facilitates high reaction rate of E. coli FAS malonyl-CoA:ACP transacylase, FabD.
      Title: Interfacial plasticity facilitates high reaction rate of E. coli FAS malonyl-CoA:ACP transacylase, FabD.
    2. N-terminus verified by Edman degradation on mature peptide
      Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
    3. A possible new catalytic enzyme mechanism is discussed for FabD.
      Title: Mapping the active site of Escherichia coli malonyl-CoA-acyl carrier protein transacylase (FabD) by protein crystallography.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables [acyl-carrier-protein] S-malonyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables [acyl-carrier-protein] S-malonyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables [acyl-carrier-protein] S-malonyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    [acyl-carrier-protein] S-malonyltransferase
    NP_415610.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1149728..1150657
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415610.1 [acyl-carrier-protein] S-malonyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415610.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      D0VE86
      Conserved Domains (1) summary
      TIGR00128
      Location:2 → 292
      fabD; malonyl CoA-acyl carrier protein transacylase
    Nucleotide Protein
    Heading Accession and Version

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