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    dhaL dihydroxyacetone kinase subunit L [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945748, updated on 3-Dec-2024

    Summary

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    Official Symbol
    dhaL
    Official Full Name
    dihydroxyacetone kinase subunit L
    Primary source
    ECOCYC:G6626
    Locus tag
    b1199
    See related
    ASAP:ABE-0004026
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    dhaK2; ECK1187; ycgS; ysgS
    Summary
    DhaL is similar to C-terminal half of single protein DHA kinases. [More information is available at EcoGene: EG13900]. The L subunit is similar to the C-terminal half of ATP-dependent dihydroxyacetone kinases of eukaryotes and other bacteria. [More information is available at EcoCyc: G6626].
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    Genomic context

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    Sequence:
    NC_000913.3 (1249125..1249757, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene periplasmic trehalase Neighboring gene dihydroxyacetone kinase subunit M Neighboring gene dihydroxyacetone kinase subunit K Neighboring gene DNA-binding transcriptional dual regulator DhaR

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the nucleotide-binding subunit DhaL of the Escherichia coli dihydroxyacetone kinase. Oberholzer AE, et al. J Mol Biol, 2006 Jun 9. PMID 16647083
    2. Structural and mechanistic insight into covalent substrate binding by Escherichia coli dihydroxyacetone kinase. Shi R, et al. Proc Natl Acad Sci U S A, 2011 Jan 25. PMID 21209328, Free PMC Article
    3. Heterodimeric dihydroxyacetone kinase from a ptsI mutant of Escherichia coli. Beutler R, et al. Microbiology (Reading), 2001 Feb. PMID 11158340
    4. From ATP as substrate to ADP as coenzyme: functional evolution of the nucleotide binding subunit of dihydroxyacetone kinases. Bächler C, et al. J Biol Chem, 2005 May 6. PMID 15753087
    5. A mechanism of covalent substrate binding in the x-ray structure of subunit K of the Escherichia coli dihydroxyacetone kinase. Siebold C, et al. Proc Natl Acad Sci U S A, 2003 Jul 8. PMID 12813127, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that the structure of dihydroxyacetone kinase complex DhaK undergoes significant conformational changes to accommodate binding of DhaL.
      Title: Structural and mechanistic insight into covalent substrate binding by Escherichia coli dihydroxyacetone kinase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ADP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerone kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoenolpyruvate-glycerone phosphotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoenolpyruvate-glycerone phosphotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycerol catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyruvate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dihydroxyacetone kinase subunit L
    NP_415717.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1249125..1249757 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415717.1 dihydroxyacetone kinase subunit L [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415717.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N8R0H0
      Conserved Domains (1) summary
      PRK10005
      Location:1 → 210
      PRK10005; dihydroxyacetone kinase ADP-binding subunit DhaL
    Nucleotide Protein
    Heading Accession and Version

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