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    lsrB Autoinducer-2 ABC transporter periplasmic binding protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945418, updated on 17-Dec-2024

    Summary

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    Official Symbol
    lsrB
    Official Full Name
    Autoinducer-2 ABC transporter periplasmic binding protein
    Primary source
    ECOCYC:G6803
    Locus tag
    b1516
    See related
    ASAP:ABE-0005063
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1509; yneA
    Summary
    Salmonella LsrB binds a chemically distinct form of the AI-2 signal, (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran (R-THMF), that lacks the boron found in Vibrio AI-2. [More information is available at EcoGene: EG13809]. LsrB is a periplasmic binding protein of a predicted ATP-dependent sugar transporter. [More information is available at EcoCyc: G6803].
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    Genomic context

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    Sequence:
    NC_000913.3 (1605051..1606073)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene Autoinducer-2 ABC transporter ATP binding subunit Neighboring gene Autoinducer-2 ABC transporter membrane subunit LsrC Neighboring gene Autoinducer-2 ABC transporter membrane subunit LsrD Neighboring gene 3-hydroxy-2,4-pentadione 5-phosphate thiolase Neighboring gene (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of functional LsrB-like autoinducer-2 receptors. Pereira CS, et al. J Bacteriol, 2009 Nov. PMID 19749048, Free PMC Article
    2. Salmonella typhimurium recognizes a chemically distinct form of the bacterial quorum-sensing signal AI-2. Miller ST, et al. Mol Cell, 2004 Sep 10. PMID 15350213
    3. Chemotaxis to the quorum-sensing signal AI-2 requires the Tsr chemoreceptor and the periplasmic LsrB AI-2-binding protein. Hegde M, et al. J Bacteriol, 2011 Feb. PMID 21097621, Free PMC Article
    4. The LuxS-dependent autoinducer AI-2 controls the expression of an ABC transporter that functions in AI-2 uptake in Salmonella typhimurium. Taga ME, et al. Mol Microbiol, 2001 Nov. PMID 11722742
    5. Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli. Xavier KB, et al. J Bacteriol, 2005 Jan. PMID 15601708, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Both LsrB and Tsr are necessary for sensing AI-2, but AI-2 uptake is not, suggesting that LsrB and Tsr interact directly in the periplasm.
      Title: Chemotaxis to the quorum-sensing signal AI-2 requires the Tsr chemoreceptor and the periplasmic LsrB AI-2-binding protein.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Process Evidence Code Pubs
    involved_in autoinducer AI-2 transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in autoinducer AI-2 transmembrane transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in quorum sensing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Autoinducer-2 ABC transporter periplasmic binding protein
    NP_416033.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1605051..1606073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416033.1 Autoinducer-2 ABC transporter periplasmic binding protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416033.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AK37, A0A8S7EHN6
      Conserved Domains (1) summary
      PRK15408
      Location:5 → 340
      PRK15408; autoinducer 2 ABC transporter substrate-binding protein LsrB
    Nucleotide Protein
    Heading Accession and Version

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