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    fumA fumarase A [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946826, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fumA
    Official Full Name
    fumarase A
    Primary source
    ECOCYC:EG10356
    Locus tag
    b1612
    See related
    ASAP:ABE-0005392
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1607
    Summary
    One of three isozymes in Escherichia coli, fumarase A is a Class I fumarase. [More information is available at EcoCyc: EG10356].
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    Genomic context

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    Sequence:
    NC_000913.3 (1686731..1688377, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene sensory histidine kinase RstB Neighboring gene DNA replication terminus site-binding protein Neighboring gene fumarase C Neighboring gene mannose-6-phosphate isomerase Neighboring gene DUF945 domain-containing protein YdgA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fumarase a from Escherichia coli: purification and characterization as an iron-sulfur cluster containing enzyme. Flint DH, et al. Biochemistry, 1992 Oct 27. PMID 1329945
    2. High growth rate downregulates fumA mRNA transcription but is dramatically compensated by its mRNA stability in Escherichia coli. Lin HH, et al. Curr Microbiol, 2012 May. PMID 22302452
    3. Nucleotide sequence and transcriptional start point of the phosphomannose isomerase gene (manA) of Escherichia coli. Miles JS, et al. Gene, 1984 Dec. PMID 6397402
    4. Regulatory role of cAMP receptor protein over Escherichia coli fumarase genes. Chen YP, et al. J Microbiol, 2012 Jun. PMID 22752906
    5. Escherichia coli di-iron YtfE protein is necessary for the repair of stress-damaged iron-sulfur clusters. Justino MC, et al. J Biol Chem, 2007 Apr 6. PMID 17289666

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results show that Crp is an activator of fumA and fumC gene expression under various oxygen conditions and growth rates.
      Title: Regulatory role of cAMP receptor protein over Escherichia coli fumarase genes.
    2. The half-life of fumA mRNA was increased by fivefold when the growth rate was increased to 0.96/h.
      Title: High growth rate downregulates fumA mRNA transcription but is dramatically compensated by its mRNA stability in Escherichia coli.
    3. N-terminus verified by Edman degradation on mature peptide
      Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fumarate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fumarate hydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fumarate hydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fumarate hydratase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxaloacetate tautomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxaloacetate tautomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in generation of precursor metabolites and energy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tricarboxylic acid cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fumarase A
    NP_416129.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1686731..1688377 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416129.1 fumarase A [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416129.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376M7B2
      Conserved Domains (1) summary
      PRK15389
      Location:2 → 537
      PRK15389; fumarate hydratase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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