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    malX PTS enzyme IIBC component MalX [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946009, updated on 3-Dec-2024

    Summary

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    Official Symbol
    malX
    Official Full Name
    PTS enzyme IIBC component MalX
    Primary source
    ECOCYC:EG10563
    Locus tag
    b1621
    See related
    ASAP:ABE-0005429
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1616
    Summary
    Crp activated. [More information is available at EcoGene: EG10563]. [More information is available at EcoCyc: EG10563].
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    Genomic context

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    Sequence:
    NC_000913.3 (1699355..1700947)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 7-alpha-hydroxysteroid dehydrogenase Neighboring gene DNA-binding transcriptional repressor MalI Neighboring gene negative regulator of MalT activity/cystathionine beta-lyase Neighboring gene adenosine deaminase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcription initiation in the Escherichia coli K-12 malI-malX intergenic region and the role of the cyclic AMP receptor protein. Lloyd GS, et al. FEMS Microbiol Lett, 2008 Nov. PMID 19054084
    2. Evolution of transcriptional regulation system through promiscuous coupling of regulatory proteins with operons; suggestion from protein sequence similarities in Escherichia coli. Otsuka J, et al. J Theor Biol, 1996 Jan 21. PMID 8729576
    3. MalI, a novel protein involved in regulation of the maltose system of Escherichia coli, is highly homologous to the repressor proteins GalR, CytR, and LacI. Reidl J, et al. J Bacteriol, 1989 Sep. PMID 2670898, Free PMC Article
    4. New targets for the cyclic AMP receptor protein in the Escherichia coli K-12 genome. Hollands K, et al. FEMS Microbiol Lett, 2007 Sep. PMID 17608696
    5. The malX malY operon of Escherichia coli encodes a novel enzyme II of the phosphotransferase system recognizing glucose and maltose and an enzyme abolishing the endogenous induction of the maltose system. Reidl J, et al. J Bacteriol, 1991 Aug. PMID 1856179, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression from the malX promoter is dependent on binding of the cyclic AMP receptor protein (CRP) to a DNA site centred 41.5 bp upstream of the transcript start.
      Title: Transcription initiation in the Escherichia coli K-12 malI-malX intergenic region and the role of the cyclic AMP receptor protein.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables D-glucose transmembrane transporter activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables maltose transmembrane transporter activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-N(PI)-phosphohistidine-sugar phosphotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-phosphocysteine-glucose phosphotransferase system transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within D-glucose import EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in D-glucose transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbohydrate utilization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within maltose transport EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in phosphoenolpyruvate-dependent sugar phosphotransferase system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphoenolpyruvate-dependent sugar phosphotransferase system IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PTS enzyme IIBC component MalX

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1699355..1700947
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416138.1 PTS enzyme IIBC component MalX [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416138.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAN3PZD1
      Conserved Domains (1) summary
      PRK10110
      Location:1 → 530
      PRK10110; PTS maltose transporter subunit IICB
    Nucleotide Protein
    Heading Accession and Version

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