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    lpxM Lipid A biosynthesis myristoyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945143, updated on 17-Dec-2024

    Summary

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    Official Symbol
    lpxM
    Official Full Name
    Lipid A biosynthesis myristoyltransferase
    Primary source
    ECOCYC:EG10614
    Locus tag
    b1855
    See related
    ASAP:ABE-0006185
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1856; mlt; msbB; waaN
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    Genomic context

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    Sequence:
    NC_000913.3 (1939222..1940193, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor YebK Neighboring gene pyruvate kinase 2 Neighboring gene peptidoglycan endopeptidase MepM Neighboring gene Zn(2(+)) ABC transporter periplasmic binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of the lpxM lipid A biosynthesis pathway gene in pathogenicity of avian pathogenic Escherichia coli strain E058 in a chicken infection model. Xu H, et al. Vet Microbiol, 2013 Oct 25. PMID 23856328
    2. Function of the Escherichia coli msbB gene, a multicopy suppressor of htrB knockouts, in the acylation of lipid A. Acylation by MsbB follows laurate incorporation by HtrB. Clementz T, et al. J Biol Chem, 1997 Apr 18. PMID 9099672
    3. Escherichia coli msbB gene as a virulence factor and a therapeutic target. Somerville JE Jr, et al. Infect Immun, 1999 Dec. PMID 10569778, Free PMC Article
    4. Resistance to the antimicrobial peptide polymyxin requires myristoylation of Escherichia coli and Salmonella typhimurium lipid A. Tran AX, et al. J Biol Chem, 2005 Aug 5. PMID 15951433
    5. Extragenic suppressors of growth defects in msbB Salmonella. Murray SR, et al. J Bacteriol, 2001 Oct. PMID 11544217, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. lpxM gene is important for the pathogenicity and biological activity.
      Title: Role of the lpxM lipid A biosynthesis pathway gene in pathogenicity of avian pathogenic Escherichia coli strain E058 in a chicken infection model.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myristoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Kdo2-lipid A biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Kdo2-lipid A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Gram-negative-bacterium-type cell wall IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Lipid A biosynthesis myristoyltransferase
    NP_416369.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1939222..1940193 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416369.1 Lipid A biosynthesis myristoyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416369.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A797I116, A0A8S7RY74, A0AAN5UFB2
      Conserved Domains (1) summary
      PRK08943
      Location:1 → 321
      PRK08943; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Validated
    Nucleotide Protein
    Heading Accession and Version

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