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    hisI putative bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946515, updated on 3-Dec-2024

    Summary

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    Official Symbol
    hisI
    Official Full Name
    putative bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase
    Primary source
    ECOCYC:EG10451
    Locus tag
    b2026
    See related
    ASAP:ABE-0006729
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2021; hisE; hisIE
    Summary
    After four hours of Zn(II) stress, HisJ protein levels decreased (Easton, 2006). [More information is available at EcoGene: EG10451]. HisI is predicted to be a bifunctional enzyme carrying out the second and third steps in the biosynthesis of histidine. [More information is available at EcoCyc: EG10451].
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    Genomic context

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    Sequence:
    NC_000913.3 (2096614..2097225)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene histidinol-phosphate aminotransferase Neighboring gene imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase Neighboring gene imidazole glycerol phosphate synthase subunit HisH Neighboring gene 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase Neighboring gene imidazole glycerol phosphate synthase subunit HisF Neighboring gene O-antigen co-polymerase Neighboring gene UDP-glucose 6-dehydrogenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conservation of primary structure in the hisI gene of the archaebacterium, Methanococcus vannielii, the eubacterium Escherichia coli, and the eucaryote Saccharomyces cerevisiae. Beckler GS, et al. Mol Gen Genet, 1986 Jul. PMID 3018439
    2. PHOSPHORIBOSYLADENOSINE MONOPHOSPHATE, AN INTERMEDIATE IN HISTIDINE BIOSYNTHESIS. SMITH DW, et al. J Biol Chem, 1965 Jul. PMID 14342333
    3. Powerful mutator activity of the polA1 mutation within the histidine region of Escherichia coli K-12. Savić DJ, et al. J Bacteriol, 1982 Mar. PMID 7037745, Free PMC Article
    4. Isolation and characterization of a histidine biosynthetic gene in Arabidopsis encoding a polypeptide with two separate domains for phosphoribosyl-ATP pyrophosphohydrolase and phosphoribosyl-AMP cyclohydrolase. Fujimori K, et al. Plant Physiol, 1998 Sep. PMID 9733547, Free PMC Article
    5. Nucleotide sequence of the Escherichia coli hisD gene and of the Escherichia coli and Salmonella typhimurium hisIE region. Chiariotti L, et al. Mol Gen Genet, 1986 Jun. PMID 3018428

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosyl-AMP cyclohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosyl-AMP cyclohydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables phosphoribosyl-ATP diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosyl-ATP diphosphatase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-histidine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within L-histidine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase
    NP_416530.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2096614..2097225
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416530.1 putative bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416530.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9GDT4
      Conserved Domains (1) summary
      PRK02759
      Location:3 → 202
      PRK02759; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE
    Nucleotide Protein
    Heading Accession and Version

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