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    rcnA Ni(2(+))/Co(2(+)) exporter [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 949078, updated on 3-Dec-2024

    Summary

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    Official Symbol
    rcnA
    Official Full Name
    Ni(2(+))/Co(2(+)) exporter
    Primary source
    ECOCYC:G7138
    Locus tag
    b2106
    See related
    ASAP:ABE-0006968
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2099; yohM
    Summary
    Induced by nickel or cobalt. [More information is available at EcoGene: EG14071]. RcnA is a membrane-bound efflux system for nickel and cobalt resistance. rcnA mutants showed decreased resistance to nickel and cobalt. [More information is available at EcoCyc: G7138].
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    Genomic context

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    Sequence:
    NC_000913.3 (2185917..2186741)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase Neighboring gene hydroxyethylthiazole kinase Neighboring gene DNA-binding transcriptional repressor RcnR Neighboring gene periplasmic protein involved in nickel/cobalt export Neighboring gene putative fimbrial adhesin YehA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nickel promotes biofilm formation by Escherichia coli K-12 strains that produce curli. Perrin C, et al. Appl Environ Microbiol, 2009 Mar. PMID 19168650, Free PMC Article
    2. The RcnRA (YohLM) system of Escherichia coli: a connection between nickel, cobalt and iron homeostasis. Koch D, et al. Biometals, 2007 Oct. PMID 17120142
    3. The Escherichia coli metallo-regulator RcnR represses rcnA and rcnR transcription through binding on a shared operator site: Insights into regulatory specificity towards nickel and cobalt. Blaha D, et al. Biochimie, 2011 Mar. PMID 21040754
    4. Ni(II) and Co(II) sensing by Escherichia coli RcnR. Iwig JS, et al. J Am Chem Soc, 2008 Jun 18. PMID 18505253, Free PMC Article
    5. Identification of rcnA (yohM), a nickel and cobalt resistance gene in Escherichia coli. Rodrigue A, et al. J Bacteriol, 2005 Apr. PMID 15805538, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables nickel cation transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nickel cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nickel cation transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cobalt ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular nickel ion homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nickel cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nickel cation transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nickel cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to cobalt ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to cobalt ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to nickel cation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to nickel cation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ni(2(+))/Co(2(+)) exporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2185917..2186741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416609.1 Ni(2(+))/Co(2(+)) exporter [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416609.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1V2GFY8, A0AAN3TSF8
      Conserved Domains (1) summary
      PRK10019
      Location:1 → 274
      PRK10019; nickel/cobalt efflux transporter RcnA
    Nucleotide Protein
    Heading Accession and Version

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