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    preT dihydropyrimidine dehydrogenase (NAD(+)) subunit PreT [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 949049, updated on 17-Dec-2024

    Summary

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    Official Symbol
    preT
    Official Full Name
    dihydropyrimidine dehydrogenase (NAD(+)) subunit PreT
    Primary source
    ECOCYC:G7145
    Locus tag
    b2146
    See related
    ASAP:ABE-0007096
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2139; yeiT
    Summary
    AFMB Structural Genomics target Number 63 (http://afmb.cnrs-mrs.fr/article171.html). [More information is available at EcoGene: EG14074]. Based on sequence similarity, YeiT is predicted to be a dihydrothymine dehydrogenase . [More information is available at EcoCyc: G7145].
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    Genomic context

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    Sequence:
    NC_000913.3 (2234033..2235271)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF218 domain-containing protein SanA Neighboring gene DUF2542 domain-containing protein YeiS Neighboring gene dihydropyrimidine dehydrogenase (NAD(+)) subunit PreA Neighboring gene D-galactose/methyl-galactoside ABC transporter membrane subunit Neighboring gene D-galactose/methyl-galactoside ABC transporter ATP binding subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression and characterization of Escherichia coli dihydropyrimidine dehydrogenase: a four iron-sulphur cluster containing flavoprotein. Yoshioka H, et al. J Biochem, 2021 Dec 4. PMID 34097066
    2. Escherichia coli dihydropyrimidine dehydrogenase is a novel NAD-dependent heterotetramer essential for the production of 5,6-dihydrouracil. Hidese R, et al. J Bacteriol, 2011 Feb. PMID 21169495, Free PMC Article
    3. The iscS gene deficiency affects the expression of pyrimidine metabolism genes. Mihara H, et al. Biochem Biophys Res Commun, 2008 Aug 1. PMID 18482579
    4. Global gene expression in Escherichia coli biofilms. Schembri MA, et al. Mol Microbiol, 2003 Apr. PMID 12657059
    5. Flavoprotein disulfide reductases: advances in chemistry and function. Argyrou A, et al. Prog Nucleic Acid Res Mol Biol, 2004. PMID 15210329

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    contributes_to 4 iron, 4 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NADH dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to dihydropyrimidine dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dihydropyrimidine dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to flavin adenine dinucleotide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables iron-sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in pyrimidine nucleobase catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in thymine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in uracil catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of dihydropyrimidine dehydrogenase (NAD+) complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of oxidoreductase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dihydropyrimidine dehydrogenase (NAD(+)) subunit PreT
    NP_416651.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2234033..2235271
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416651.1 dihydropyrimidine dehydrogenase (NAD(+)) subunit PreT [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416651.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376U6U7, A0A8S7I0R1
      Conserved Domains (1) summary
      PRK11749
      Location:3 → 412
      PRK11749; dihydropyrimidine dehydrogenase subunit A; Provisional
    Nucleotide Protein
    Heading Accession and Version

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