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    arnF undecaprenyl-phosphate-alpha-L-Ara4N flippase - ArnF subunit [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945344, updated on 3-Dec-2024

    Summary

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    Official Symbol
    arnF
    Official Full Name
    undecaprenyl-phosphate-alpha-L-Ara4N flippase - ArnF subunit
    Primary source
    ECOCYC:G7171
    Locus tag
    b2258
    See related
    ASAP:ABE-0007466
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2252; yfbJ
    Summary
    Involved in the modification of lipid A phosphates with aminoarabinose that is required for polymyxin B and cationic antimicrobial peptide resistance. [More information is available at EcoGene: EG14094]. ArnF is an integral membrane component of the ArnE/ArnF undecaprenyl-phosphate--L-Ara4N flippase. [More information is available at EcoCyc: G7171].
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    Genomic context

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    Sequence:
    NC_000913.3 (2372892..2373278)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene fused UDP-4-amino-4-deoxy-L-arabinose formyltransferase/UDP-glucuronate dehydrogenase Neighboring gene putative 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD Neighboring gene lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase Neighboring gene undecaprenyl-phosphate-alpha-L-Ara4N flippase - ArnE subunit Neighboring gene signal transduction protein PmrD Neighboring gene o-succinylbenzoate--CoA ligase Neighboring gene o-succinylbenzoate synthase Neighboring gene 1,4-dihydroxy-2-naphthoyl-CoA synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The pleiotropic two-component regulatory system PhoP-PhoQ. Groisman EA. J Bacteriol, 2001 Mar. PMID 11222580, Free PMC Article
    2. Fe(III)-mediated cellular toxicity. Chamnongpol S, et al. Mol Microbiol, 2002 Aug. PMID 12139617
    3. Role of Mg2+ and pH in the modification of Salmonella lipid A after endocytosis by macrophage tumour cells. Gibbons HS, et al. Mol Microbiol, 2005 Jan. PMID 15659161
    4. An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli. Yan A, et al. J Biol Chem, 2007 Dec 7. PMID 17928292, Free PMC Article
    5. Accumulation of a polyisoprene-linked amino sugar in polymyxin-resistant Salmonella typhimurium and Escherichia coli: structural characterization and transfer to lipid A in the periplasm. Trent MS, et al. J Biol Chem, 2001 Nov 16. PMID 11535605

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables carbohydrate derivative transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbohydrate derivative transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate derivative transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to iron(III) ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to iron(III) ion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    undecaprenyl-phosphate-alpha-L-Ara4N flippase - ArnF subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2372892..2373278
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416761.4 undecaprenyl-phosphate-alpha-L-Ara4N flippase - ArnF subunit [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416761.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1X3JEH5
      Conserved Domains (1) summary
      PRK02971
      Location:1 → 128
      PRK02971; 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional
    Nucleotide Protein
    Heading Accession and Version

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