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    fadL long-chain fatty acid outer membrane channel/bacteriophage T2 receptor [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946820, updated on 17-Dec-2024

    Summary

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    Official Symbol
    fadL
    Official Full Name
    long-chain fatty acid outer membrane channel/bacteriophage T2 receptor
    Primary source
    ECOCYC:EG10280
    Locus tag
    b2344
    See related
    ASAP:ABE-0007740
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2338; ttr
    Summary
    FadL is an outer membrane protein involved with the uptake of long-chain fatty acids . [More information is available at EcoCyc: EG10280].
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    Genomic context

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    Sequence:
    NC_000913.3 (2461306..2462646)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 3-hydroxyacyl-CoA dehydrogenase FadJ Neighboring gene 3-ketoacyl-CoA thiolase FadI Neighboring gene DUF406 domain-containing protein YfcZ Neighboring gene protein YfdF Neighboring gene intermembrane phospholipid transport system - outer membrane lipoprotein MlaA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The fadL gene product of Escherichia coli is an outer membrane protein required for uptake of long-chain fatty acids and involved in sensitivity to bacteriophage T2. Black PN. J Bacteriol, 1988 Jun. PMID 3286621, Free PMC Article
    2. The amino-terminal region of the long-chain fatty acid transport protein FadL contains an externally exposed domain required for bacteriophage T2 binding. Cristalli G, et al. Arch Biochem Biophys, 2000 May 15. PMID 10845710
    3. Osmoregulation of the fatty acid receptor gene fadL in Escherichia coli. Higashitani A, et al. Mol Gen Genet, 1993 Sep. PMID 8413182
    4. Bacterial long-chain fatty acid transport. Identification of amino acid residues within the outer membrane protein FadL required for activity. Kumar GB, et al. J Biol Chem, 1993 Jul 25. PMID 8340375
    5. Crystal structure of the long-chain fatty acid transporter FadL. van den Berg B, et al. Science, 2004 Jun 4. PMID 15178802

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CRP-cAMP complex directly activates expression of fadL and fadD genes.
      Title: Crosstalk of Escherichia coli FadR with global regulators in expression of fatty acid transport genes.
    2. Data show that high-affinity (submicromolar) substrate binding to the outer membrane long-chain fatty acid transporter FadL from Escherichia coli causes conformational changes in the N terminus that open up a channel for substrate diffusion.
      Title: Ligand-gated diffusion across the bacterial outer membrane.
    3. N-terminus verified by Edman degradation on mature peptide
      Title: Amounts of proteins altered by mutations in the dnaA gene of Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ligand-gated channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables long-chain fatty acid transporting porin activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables long-chain fatty acid transporting porin activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain fatty acid transporting porin activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within long-chain fatty acid transport EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    long-chain fatty acid outer membrane channel/bacteriophage T2 receptor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2461306..2462646
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416846.2 long-chain fatty acid outer membrane channel/bacteriophage T2 receptor [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416846.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1X3J2W2, A0A1X3JER8, A0A979H2N4, A0AAN3MAG7, A0AAX0PNH7, B7LBJ8, B7N5V5, D3H227, F4T0R5
      Conserved Domains (1) summary
      PRK10716
      Location:1 → 446
      PRK10716; long-chain fatty acid transporter FadL
    Nucleotide Protein
    Heading Accession and Version

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