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    fucU L-fucose mutarotase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945842, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fucU
    Official Full Name
    L-fucose mutarotase
    Primary source
    ECOCYC:EG10355
    Locus tag
    b2804
    See related
    ASAP:ABE-0009193
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2799
    Summary
    Utilizing NMR techniques, FucU was shown to catalyze the anomeric conversion of fucose. [More information is available at EcoCyc: EG10355].
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    Genomic context

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    Sequence:
    NC_000913.3 (2938888..2939310)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene L-fucose isomerase Neighboring gene L-fuculokinase Neighboring gene DNA-binding transcriptional activator FucR Neighboring gene 23S rRNA 2'-O-ribose C2498 methyltransferase Neighboring gene DUF423 domain-containing inner membrane protein YgdD

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structures and enzyme mechanisms of a dual fucose mutarotase/ribose pyranase. Lee KH, et al. J Mol Biol, 2009 Aug 7. PMID 19524593
    2. Constitutive activation of the fucAO operon and silencing of the divergently transcribed fucPIK operon by an IS5 element in Escherichia coli mutants selected for growth on L-1,2-propanediol. Chen YM, et al. J Bacteriol, 1989 Nov. PMID 2553671, Free PMC Article
    3. The nucleotide sequence of Escherichia coli genes for L-fucose dissimilation. Lu Z, et al. Nucleic Acids Res, 1989 Jun 26. PMID 2664711, Free PMC Article
    4. Genome-wide screening of genes required for swarming motility in Escherichia coli K-12. Inoue T, et al. J Bacteriol, 2007 Feb. PMID 17122336, Free PMC Article
    5. Crystal structures of RbsD leading to the identification of cytoplasmic sugar-binding proteins with a novel folding architecture. Kim MS, et al. J Biol Chem, 2003 Jul 25. PMID 12738765

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. E. coli FucU forms a decameric toroid with each active site formed by two adjacent subunits.
      Title: Crystal structures and enzyme mechanisms of a dual fucose mutarotase/ribose pyranase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables D-ribose pyranase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-fucose mutarotase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-fucose mutarotase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fucose binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fucose binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fucose binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables racemase and epimerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables racemase and epimerase activity, acting on carbohydrates and derivatives IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables racemase and epimerase activity, acting on carbohydrates and derivatives IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-fucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fucosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    L-fucose mutarotase
    NP_417284.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2938888..2939310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417284.1 L-fucose mutarotase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417284.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5C9ACM7
      Conserved Domains (1) summary
      PRK15420
      Location:1 → 140
      fucU; L-fucose mutarotase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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