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    mug stationary phase mismatch/uracil DNA glycosylase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947560, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mug
    Official Full Name
    stationary phase mismatch/uracil DNA glycosylase
    Primary source
    ECOCYC:EG12717
    Locus tag
    b3068
    See related
    ASAP:ABE-0010073
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3058; ygjF
    Summary
    Endonuclease IV stimulates Mug activity in vitro by promoting disassociation from the DNA and enzyme turnover. [More information is available at EcoGene: EG12717]. Mug is a glycosylase that acts in DNA repair . [More information is available at EcoCyc: EG12717].
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    Genomic context

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    Sequence:
    NC_000913.3 (3214967..3215473, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA primase Neighboring gene RNA polymerase sigma factor RpoD Neighboring gene tRNA-Ile Neighboring gene NADPH-dependent ferric-chelate reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Thermostable uracil-DNA glycosylase from Thermotoga maritima a member of a novel class of DNA repair enzymes. Sandigursky M, et al. Curr Biol, 1999 May 20. PMID 10339434
    2. Novel activity of Escherichia coli mismatch uracil-DNA glycosylase (Mug) excising 8-(hydroxymethyl)-3,N4-ethenocytosine, a potential product resulting from glycidaldehyde reaction. Hang B, et al. Biochemistry, 2002 Feb 19. PMID 11841206
    3. Crystal structure of a thwarted mismatch glycosylase DNA repair complex. Barrett TE, et al. EMBO J, 1999 Dec 1. PMID 10581234, Free PMC Article
    4. Influence of local duplex stability and N6-methyladenine on uracil recognition by mismatch-specific uracil-DNA glycosylase (Mug). Valinluck V, et al. Chem Res Toxicol, 2002 Dec. PMID 12482242
    5. Repair of the mutagenic DNA oxidation product, 5-formyluracil. Liu P, et al. DNA Repair (Amst), 2003 Feb 3. PMID 12531390

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. E. coli MUG is able to excise 8oxoA in 8oxoA*T pairs.
      Title: 7,8-Dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases.
    2. Mug glycosylase is engaged in the repair of Etheno-DNA adducts.
      Title: The role of AlkB protein in repair of 1,N⁶-ethenoadenine in Escherichia coli cells.
    3. Mug binds its product cooperatively, and a stoichiometric analysis of DNA binding, catalytic activity and salt-dependence indicates that dimer formation is of functional significance in both catalytic activity and product binding.
      Title: Differential modes of DNA binding by mismatch uracil DNA glycosylase from Escherichia coli: implications for abasic lesion processing and enzyme communication in the base excision repair pathway.
    4. Escherichia coli mismatch-specific uracil DNA glycosylase is a robust xanthine DNA glycosylase
      Title: Identification of Escherichia coli mismatch-specific uracil DNA glycosylase as a robust xanthine DNA glycosylase.
    5. The enzymatic activity of E. coli mismatch-specific uracil-DNA glycosylase (MUG)can be complemented by human thymine-DNA glycosylase (hTDG).
      Title: Role of mismatch-specific uracil-DNA glycosylase in repair of 3,N4-ethenocytosine in vivo.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G/U mismatch-specific uracil-DNA glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mismatch base pair DNA N-glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyrimidine-specific mismatch base pair DNA N-glycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyrimidine-specific mismatch base pair DNA N-glycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyrimidine-specific mismatch base pair DNA N-glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uracil DNA N-glycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in base-excision repair, AP site formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within base-excision repair, AP site formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in base-excision repair, AP site formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    stationary phase mismatch/uracil DNA glycosylase
    NP_417540.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3214967..3215473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417540.1 stationary phase mismatch/uracil DNA glycosylase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417540.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6L7CFQ5
      Conserved Domains (2) summary
      PRK10201
      Location:1 → 168
      PRK10201; G/U mismatch-specific DNA glycosylase
      cd10028
      Location:16 → 20
      UDG-F2_TDG_MUG; motif A [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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