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    tdcC threonine/serine:H(+) symporter [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947629, updated on 3-Dec-2024

    Summary

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    Official Symbol
    tdcC
    Official Full Name
    threonine/serine:H(+) symporter
    Primary source
    ECOCYC:EG10991
    Locus tag
    b3116
    See related
    ASAP:ABE-0010247
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3105
    Summary
    HAAAP family. [More information is available at EcoGene: EG10991]. TdcC is a threonine transport system, likely to function as a threonine/proton symporter. [More information is available at EcoCyc: EG10991].
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    Genomic context

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    Sequence:
    NC_000913.3 (3263686..3265017, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 2-ketobutyrate formate-lyase/pyruvate formate-lyase 4 Neighboring gene propionate kinase Neighboring gene catabolic threonine dehydratase Neighboring gene DNA-binding transcriptional activator TdcA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel membrane-associated threonine permease encoded by the tdcC gene of Escherichia coli. Sumantran VN, et al. J Bacteriol, 1990 Aug. PMID 2115866, Free PMC Article
    2. Isolation and characterization of an Escherichia coli mutant lacking the major serine transporter, and cloning of a serine transporter gene. Ogawa W, et al. J Biochem, 1997 Dec. PMID 9498571
    3. Deletion of arcA, iclR, and tdcC in Escherichia coli to improve l-threonine production. Ding Z, et al. Biotechnol Appl Biochem, 2019 Sep. PMID 31177569
    4. Integration host factor is required for positive regulation of the tdc operon of Escherichia coli. Wu YF, et al. J Bacteriol, 1992 Jan. PMID 1729211, Free PMC Article
    5. Physical linkage and transcriptional orientation of the tdc operon on the Escherichia coli chromosome. Schweizer HP, et al. Mol Gen Genet, 1991 Aug. PMID 1886605

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results suggest that deletion of arcA, iclR, and tdcC could efficiently increase l-threonine production in E. coli.
      Title: Deletion of arcA, iclR, and tdcC in Escherichia coli to improve l-threonine production.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables L-serine transmembrane transporter activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables L-serine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-serine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables L-threonine transmembrane transporter activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables L-threonine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables amino acid transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables solute:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables threonine efflux transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-serine transport EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within L-serine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in amino acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within amino acid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in serine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within threonine transport EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in threonine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within threonine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    threonine/serine:H(+) symporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3263686..3265017 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417586.1 threonine/serine:H(+) symporter [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417586.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A377C4J2
      Conserved Domains (1) summary
      PRK13629
      Location:1 → 443
      PRK13629; threonine/serine transporter TdcC; Provisional
    Nucleotide Protein
    Heading Accession and Version

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