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    secY Sec translocon subunit SecY [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947799, updated on 3-Dec-2024

    Summary

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    Official Symbol
    secY
    Official Full Name
    Sec translocon subunit SecY
    Primary source
    ECOCYC:EG10766
    Locus tag
    b3300
    See related
    ASAP:ABE-0010814
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3287; prlA
    Summary
    SecYEG complex interacts with SecDFyajC to form a hexameric holocomplex. [More information is available at EcoGene: EG10766]. SecY is a protein involved in the Sec protein secretion pathway. [More information is available at EcoCyc: EG10766].
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    Genomic context

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    Sequence:
    NC_000913.3 (3442766..3444097, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 30S ribosomal subunit protein S13 Neighboring gene 50S ribosomal subunit protein L36 Neighboring gene 50S ribosomal subunit protein L15 Neighboring gene 50S ribosomal subunit protein L30

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The SecY translocation complex: convergence of genetics and structure. Flower AM. Trends Microbiol, 2007 May. PMID 17368028
    2. The SecY membrane component of the bacterial protein export machinery: analysis by new electrophoretic methods for integral membrane proteins. Akiyama Y, et al. EMBO J, 1985 Dec 1. PMID 3004955, Free PMC Article
    3. The secY protein can act post-translationally to promote bacterial protein export. Bacallao R, et al. J Biol Chem, 1986 Sep 25. PMID 3017993
    4. A previously unidentified gene in the spc operon of Escherichia coli K12 specifies a component of the protein export machinery. Shultz J, et al. Cell, 1982 Nov. PMID 6297749
    5. A defined mutation in the protein export gene within the spc ribosomal protein operon of Escherichia coli: isolation and characterization of a new temperature-sensitive secY mutant. Shiba K, et al. EMBO J, 1984 Mar. PMID 6370688, Free PMC Article

    See all (191) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Comparison of Single and Multiple Turnovers of SecYEG in Escherichia coli.
      Title: Comparison of Single and Multiple Turnovers of SecYEG in Escherichia coli.
    2. SecY-mediated quality control prevents the translocation of non-gated porins.
      Title: SecY-mediated quality control prevents the translocation of non-gated porins.
    3. Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation.
      Title: Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation.
    4. SecA gains access to the SecYEG complex via a lipid-bound intermediate state, whereas acidic phospholipids allosterically activate SecA for ATP-dependent protein translocation.
      Title: Lipids Activate SecA for High Affinity Binding to the SecYEG Complex.
    5. Authors show that SecG plays a critical role for the residual export mediated by mutant signal sequences and that the SecYE dimer can often be detected only in the presence of SecG.
      Title: Escherichia coli SecG is required for residual export mediated by mutant signal sequences and for SecY-SecE complex stability.
    6. Study shows that SecA moves polypeptides through the SecY channel by a "push and slide" mechanism. In its ATP-bound state, SecA interacts through a two-helix finger with a subset of amino acids in a substrate, pushing them into the channel.
      Title: A "push and slide" mechanism allows sequence-insensitive translocation of secretory proteins by the SecA ATPase.
    7. These data suggest that wild-type YidC residues (G355 and M471) participate in interactions, direct or indirect, with SecY.
      Title: Identification of YidC residues that define interactions with the Sec Apparatus.
    8. The hydrophobicity threshold for SecYEG-mediated cell membrane insertion is distinctly lower than that for Sec61-mediated insertion.
      Title: Quantitative analysis of SecYEG-mediated insertion of transmembrane α-helices into the bacterial inner membrane.
    9. Data show that ribosome binding is sufficient to open the SecYEG channel.
      Title: The bacterial translocon SecYEG opens upon ribosome binding.
    10. Data indicate taht SecG inversion occurs only when MPIase associates with SecYEG.
      Title: Glycolipozyme MPIase is essential for topology inversion of SecG during preprotein translocation.
    Submit: New GeneRIF Correction See all GeneRIFs (36)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signal sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signal sequence binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within SRP-dependent cotranslational protein targeting to membrane, translocation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular protein transmembrane transport EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular protein transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular protein transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular protein transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein insertion into membrane from inner side IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein insertion into membrane from inner side IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein targeting IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein transport by the Sec complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein transport by the Sec complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein transport by the Sec complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein transport by the Sec complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cell envelope Sec protein transport complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cell envelope Sec protein transport complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cell envelope Sec protein transport complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sec translocon subunit SecY

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3442766..3444097 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417759.1 Sec translocon subunit SecY [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417759.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1V2GIN7
      Conserved Domains (1) summary
      PRK09204
      Location:18 → 433
      secY; preprotein translocase subunit SecY; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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