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    arsC arsenate reductase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948018, updated on 3-Dec-2024

    Summary

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    Official Symbol
    arsC
    Official Full Name
    arsenate reductase
    Primary source
    ECOCYC:EG12237
    Locus tag
    b3503
    See related
    ASAP:ABE-0011439
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    arsG; ECK3488
    Summary
    ArsC reduces arsenate to arsenite so it can be extruded through ArsB. [More information is available at EcoGene: EG12237]. Based on sequence similarity with the R773-plasmid encoded arsenite resistance operon, ArsB is a transporter and ArsC is an arsenate reductase . [More information is available at EcoCyc: EG12237].
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    Genomic context

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    Sequence:
    NC_000913.3 (3650237..3650662)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor ArsR Neighboring gene arsenite/antimonite:H(+) antiporter Neighboring gene pseudo Neighboring gene IS5 family transposase and trans-activator Neighboring gene starvation lipoprotein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arsenate reduction: thiol cascade chemistry with convergent evolution. Messens J, et al. J Mol Biol, 2006 Sep 8. PMID 16905151
    2. Arginine 60 in the ArsC arsenate reductase of E. coli plasmid R773 determines the chemical nature of the bound As(III) product. DeMel S, et al. Protein Sci, 2004 Sep. PMID 15295115, Free PMC Article
    3. Ligand interactions of the ArsC arsenate reductase. Liu J, et al. J Biol Chem, 1997 Aug 22. PMID 9261111
    4. Reactivity of glutaredoxins 1, 2, and 3 from Escherichia coli shows that glutaredoxin 2 is the primary hydrogen donor to ArsC-catalyzed arsenate reduction. Shi J, et al. J Biol Chem, 1999 Dec 17. PMID 10593884
    5. The ars operon of Escherichia coli confers arsenical and antimonial resistance. Carlin A, et al. J Bacteriol, 1995 Feb. PMID 7860609, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables arsenate reductase (glutaredoxin) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arsenate reductase (glutaredoxin) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to arsenic-containing substance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to arsenic-containing substance IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to arsenic-containing substance IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to arsenic-containing substance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    arsenate reductase
    NP_417960.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3650237..3650662
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417960.1 arsenate reductase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417960.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7K204
      Conserved Domains (1) summary
      PRK10026
      Location:1 → 141
      PRK10026; arsenate reductase (glutaredoxin)
    Nucleotide Protein
    Heading Accession and Version

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