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    pyrE orotate phosphoribosyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948157, updated on 17-Dec-2024

    Summary

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    Official Symbol
    pyrE
    Official Full Name
    orotate phosphoribosyltransferase
    Primary source
    ECOCYC:EG10808
    Locus tag
    b3642
    See related
    ASAP:ABE-0011904
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3632
    Summary
    This enzyme is at a low level in Escherichia coli strains W1485 and its daughters W3110 and MG1655 because of a mutation in the upstream gene affecting transcription of pyrE. [More information is available at EcoCyc: EG10808].
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    Genomic context

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    Sequence:
    NC_000913.3 (3815127..3815768, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene fused 4'-phosphopantothenoylcysteine decarboxylase and phosphopantothenoylcysteine synthetase Neighboring gene dUTP diphosphatase Neighboring gene nucleoid occlusion factor SlmA Neighboring gene truncated RNase PH Neighboring gene putative RNase adaptor protein YicC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hyper-regulation of pyr gene expression in Escherichia coli cells with slow ribosomes. Evidence for RNA polymerase pausing in vivo? Jensen KF. Eur J Biochem, 1988 Aug 15. PMID 3044790
    2. Mechanism of UTP-modulated attenuation at the pyrE gene of Escherichia coli: an example of operon polarity control through the coupling of translation to transcription. Bonekamp F, et al. EMBO J, 1984 Dec 1. PMID 6098450, Free PMC Article
    3. Nucleotide sequence of the Escherichia coli pyrE gene and of the DNA in front of the protein-coding region. Poulsen P, et al. Eur J Biochem, 1983 Sep 15. PMID 6349999
    4. Purine-mediated growth inhibition caused by a pyrE mutation in Escherichia coli K-12. Shimosaka M, et al. J Bacteriol, 1984 Dec. PMID 6389507, Free PMC Article
    5. Role of magnesium cations in the yeast orotate phosphoribosyltransferase catalyzed reaction. Mechanism of the inhibition by Cu++ and Ni++ ions. Dodin G, et al. J Inorg Biochem, 1982 Jun. PMID 7050303

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Nucleotide sequence of the Escherichia coli pyrE gene and of the DNA in front of the protein-coding region.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables orotate phosphoribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables orotate phosphoribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables orotate phosphoribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' UMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within 'de novo' pyrimidine nucleobase biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleobase-containing small molecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyrimidine nucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyrimidine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pyrimidine nucleotide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pyrimidine ribonucleoside biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyrimidine-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    orotate phosphoribosyltransferase
    NP_418099.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3815127..3815768 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418099.1 orotate phosphoribosyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418099.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A192CEN7, A0A1X3I0D7, A0A1X3JAN6, A0A829L4A9, A0AA36P8T6, A0AAN3SDL9, F4T5J5
      Conserved Domains (1) summary
      PRK00455
      Location:1 → 213
      pyrE; orotate phosphoribosyltransferase; Validated
    Nucleotide Protein
    Heading Accession and Version

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