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    adeP adenine:H(+) symporter [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948224, updated on 3-Dec-2024

    Summary

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    Official Symbol
    adeP
    Official Full Name
    adenine:H(+) symporter
    Primary source
    ECOCYC:EG11724
    Locus tag
    b3714
    See related
    ASAP:ABE-0012148
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3707; purP; yieG
    Summary
    Paralogs YicO and PurP are 74% identical and YicO may be a second adenine permease. [More information is available at EcoGene: EG11724]. PurP functions in energized high-affinity adenine uptake in Escherichia coli. [More information is available at EcoCyc: EG11724].
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    Genomic context

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    Sequence:
    NC_000913.3 (3895272..3896609, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative phosphopantetheinyl transferase Neighboring gene quinone reductase Neighboring gene 6-phosphogluconate phosphatase Neighboring gene putative inner membrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transport of adenine, hypoxanthine and uracil into Escherichia coli. Burton K. Biochem J, 1977 Nov 15. PMID 413544, Free PMC Article
    2. Conserved network of proteins essential for bacterial viability. Handford JI, et al. J Bacteriol, 2009 Aug. PMID 19376873, Free PMC Article
    3. Transport of nucleic acid bases into Escherichia coli. Burton K. J Gen Microbiol, 1983 Nov. PMID 6198438
    4. Adenine transport in Escherichia coli. Burton K. Proc Biol Sci, 1994 Feb 22. PMID 8165228
    5. Functional identification of the hypoxanthine/guanine transporters YjcD and YgfQ and the adenine transporters PurP and YicO of Escherichia coli K-12. Papakostas K, et al. J Biol Chem, 2013 Dec 27. PMID 24214977, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional identification of the hypoxanthine/guanine transporters YjcD and YgfQ and the adenine transporters PurP and YicO of Escherichia coli K-12.
      Title: Functional identification of the hypoxanthine/guanine transporters YjcD and YgfQ and the adenine transporters PurP and YicO of Escherichia coli K-12.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables adenine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nucleobase transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables solute:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adenine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within adenine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleobase transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adenine:H(+) symporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3895272..3896609 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418170.1 adenine:H(+) symporter [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418170.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T3UCD5
      Conserved Domains (1) summary
      COG2252
      Location:10 → 441
      AzgA; Xanthine/uracil/vitamin C permease, AzgA family [Nucleotide transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

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