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    asnC DNA-binding transcriptional dual regulator AsnC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948259, updated on 3-Dec-2024

    Summary

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    Official Symbol
    asnC
    Official Full Name
    DNA-binding transcriptional dual regulator AsnC
    Primary source
    ECOCYC:EG10093
    Locus tag
    b3743
    See related
    ASAP:ABE-0012237
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3737
    Summary
    Feast/famine regulatory protein. [More information is available at EcoGene: EG10093]. AsnC is a transcriptional regulator that activates the expression of asnA, a gene involved in the synthesis of asparagine . [More information is available at EcoCyc: EG10093].
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    Genomic context

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    Sequence:
    NC_000913.3 (3926545..3927003, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 5-carboxymethylaminomethyluridine-tRNA synthase subunit MnmG Neighboring gene flavoprotein MioC Neighboring gene asparagine synthetase A Neighboring gene protein ViaA Neighboring gene regulatory ATPase RavA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Site-directed mutagenesis of the Escherichia coli chromosome near oriC: identification and characterization of asnC, a regulatory element in E. coli asparagine metabolism. de Wind N, et al. Nucleic Acids Res, 1985 Dec 20. PMID 3909107, Free PMC Article
    2. Common history at the origin of the position-function correlation in transcriptional regulators in archaea and bacteria. Pérez-Rueda E, et al. J Mol Evol, 2001 Sep. PMID 11523004
    3. Termination of the Escherichia coli asnC transcript. The DnaA protein/dnaA box complex blocks transcribing RNA polymerase. Schaefer C, et al. Gene, 1988 Dec 20. PMID 2854096
    4. AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli. Kölling R, et al. J Bacteriol, 1985 Oct. PMID 2864330, Free PMC Article
    5. Expression of Escherichia coli dnaA and mioC genes as a function of growth rate. Chiaramello AE, et al. J Bacteriol, 1989 Aug. PMID 2546917, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular model of asparagine ligand binding site for the AsnC protein.
      Title: Structural insight into gene transcriptional regulation and effector binding by the Lrp/AsnC family.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to amino acid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding transcriptional dual regulator AsnC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3926545..3927003 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418199.1 DNA-binding transcriptional dual regulator AsnC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418199.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376TYI7
      Conserved Domains (1) summary
      PRK11179
      Location:1 → 152
      PRK11179; DNA-binding transcriptional regulator AsnC; Provisional
    Nucleotide Protein
    Heading Accession and Version

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