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    rfe UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948789, updated on 17-Dec-2024

    Summary

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    Official Symbol
    rfe
    Official Full Name
    UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase
    Primary source
    ECOCYC:EG10840
    Locus tag
    b3784
    See related
    ASAP:ABE-0012366
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3776; wecA
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    Genomic context

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    Sequence:
    NC_000913.3 (3967916..3969019)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene rho operon leader peptide Neighboring gene transcription termination factor Rho Neighboring gene enterobacterial common antigen polysaccharide co-polymerase Neighboring gene UDP-N-acetylglucosamine 2-epimerase Neighboring gene UDP-N-acetyl-D-mannosamine dehydrogenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification and characterization of the bacterial UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase WecA. Al-Dabbagh B, et al. J Bacteriol, 2008 Nov. PMID 18723618, Free PMC Article
    2. Functional characterization and membrane topology of Escherichia coli WecA, a sugar-phosphate transferase initiating the biosynthesis of enterobacterial common antigen and O-antigen lipopolysaccharide. Lehrer J, et al. J Bacteriol, 2007 Apr. PMID 17237164, Free PMC Article
    3. Preparative enzymatic synthesis of polyprenyl-pyrophosphoryl-N-acetylglucosamine, an essential lipid intermediate for the biosynthesis of various bacterial cell envelope polymers. Al-Dabbagh B, et al. Anal Biochem, 2009 Aug 15. PMID 19442646
    4. Biosynthesis of enterobacterial common antigen in Escherichia coli. In vitro synthesis of lipid-linked intermediates. Barr K, et al. J Biol Chem, 1987 May 25. PMID 3034883
    5. The N-terminal region of the Escherichia coli WecA (Rfe) protein, containing three predicted transmembrane helices, is required for function but not for membrane insertion. Amer AO, et al. J Bacteriol, 2000 Jan. PMID 10629198, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An enzymatic assay of WecA was developed, and the kinetic parameters as well as the effects of pH, salts, cations, detergents, and temperature on the enzyme activity were determined. A minimal length of 35 carbons was required for the lipid substrate.
      Title: Purification and characterization of the bacterial UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase WecA.
    2. characterization of the functional roles of the conserved aspartic acids of WecA
      Title: Functional characterization and membrane topology of Escherichia coli WecA, a sugar-phosphate transferase initiating the biosynthesis of enterobacterial common antigen and O-antigen lipopolysaccharide.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase
    NP_418231.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3967916..3969019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418231.1 UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418231.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A377DC17
      Conserved Domains (1) summary
      PRK15119
      Location:1 → 349
      PRK15119; UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase
    Nucleotide Protein
    Heading Accession and Version

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