U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    wzyE enterobacterial common antigen polymerase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948293, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    wzyE
    Official Full Name
    enterobacterial common antigen polymerase
    Primary source
    ECOCYC:EG11457
    Locus tag
    b3793
    See related
    ASAP:ABE-0012392
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3786; rffT
    Summary
    Mutants are blocked in ECA synthesis and accumulate Lipid III. [More information is available at EcoGene: EG11457]. wzyE has been proposed to encode the polymerase involved in the assembly of linear ECA polysaccharide chains . [More information is available at EcoCyc: EG11457].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (3978601..3979953)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene dTDP-4-dehydro-6-deoxy-D-glucose transaminase Neighboring gene lipid IIIECA flippase Neighboring gene TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase Neighboring gene UDP-N-acetyl-D-mannosaminuronic acid transferase Neighboring gene putative transporter YifK

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The role of the wzy gene in lipopolysaccharide biosynthesis and pathogenesis of avian pathogenic Escherichia coli. Zuo J, et al. Microb Pathog, 2019 Feb. PMID 30553014
    2. Genetic location of genes encoding enterobacterial common antigen. Meier U, et al. J Bacteriol, 1985 Aug. PMID 3894334, Free PMC Article
    3. The modality of enterobacterial common antigen polysaccharide chain lengths is regulated by o349 of the wec gene cluster of Escherichia coli K-12. Barr K, et al. J Bacteriol, 1999 Oct. PMID 10515954, Free PMC Article
    4. Role for Salmonella enterica enterobacterial common antigen in bile resistance and virulence. Ramos-Morales F, et al. J Bacteriol, 2003 Sep. PMID 12923112, Free PMC Article
    5. Biosynthesis and assembly of capsular polysaccharides in Escherichia coli. Whitfield C. Annu Rev Biochem, 2006. PMID 16756484

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Furthermore, an LD50 assay revealed that the virulence of mutant strain DE17Deltawzy was attenuated 132-fold compared with wild-type strain DE17.
      Title: The role of the wzy gene in lipopolysaccharide biosynthesis and pathogenesis of avian pathogenic Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables polysaccharide binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in enterobacterial common antigen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within enterobacterial common antigen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    enterobacterial common antigen polymerase

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3978601..3979953
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418241.1 enterobacterial common antigen polymerase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418241.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2W6Q7I8, A0A376FTY5, A0A5B9ANF5
      Conserved Domains (1) summary
      PRK02975
      Location:1 → 450
      PRK02975; O-antigen assembly polymerase
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.