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    corA Ni(2(+))/Co(2(+))/Mg(2(+)) transporter [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948351, updated on 3-Dec-2024

    Summary

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    Official Symbol
    corA
    Official Full Name
    Ni(2(+))/Co(2(+))/Mg(2(+)) transporter
    Primary source
    ECOCYC:EG11463
    Locus tag
    b3816
    See related
    ASAP:ABE-0012464
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3810
    Summary
    corA mutants are hypersensitivity to lactoperoxidase. otherPDB (T. maritima): [More information is available at EcoGene: EG11463]. CorA is a magnesium ion transporter that is a member of the Metal Ion Transporter (MIT) family . [More information is available at EcoCyc: EG11463].
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    Genomic context

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    Sequence:
    NC_000913.3 (4001426..4002376)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2233 domain-containing protein YigE Neighboring gene protein YsgD Neighboring gene DUF2628 domain-containing protein YigF Neighboring gene inner membrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Escherichia coli CorA periplasmic domain functions as a homotetramer to bind substrate. Wang SZ, et al. J Biol Chem, 2006 Sep 15. PMID 16835234
    2. Magnesium transport in Salmonella typhimurium: characterization of magnesium influx and cloning of a transport gene. Hmiel SP, et al. J Bacteriol, 1986 Dec. PMID 3536881, Free PMC Article
    3. Crystallization and preliminary X-ray diffraction analysis of the magnesium transporter CorA. Payandeh J, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2006 Feb 1. PMID 16511288, Free PMC Article
    4. Characterization of lactoperoxidase stress response in Escherichia coli and involvement of corA in lactoperoxidase tolerance. Sermon J, et al. Commun Agric Appl Biol Sci, 2004. PMID 15560183
    5. Possible participation of macrophage inflammatory protein 2 in neutrophil infiltration in allergic inflammation in rats. Xiao YQ, et al. Biochim Biophys Acta, 1997 Aug 22. PMID 9300795

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. findings reveal an RNase III-mediated regulatory pathway that functions to modulate corA expression and, in turn, the influx of metal ions transported by CorA in E. coli.
      Title: RNase III controls the degradation of corA mRNA in Escherichia coli.
    2. affects the lactoperoxidase sensitivity of E. coli by modulating the cytoplasmic concentrations of transition metals that enhance the toxicity of the lactoperoxidase system
      Title: CorA affects tolerance of Escherichia coli and Salmonella enterica serovar Typhimurium to the lactoperoxidase enzyme system but not to other forms of oxidative stress.
    3. the E. coli CorA periplasmic domain functions as a homotetramer for binding substrate
      Title: Escherichia coli CorA periplasmic domain functions as a homotetramer to bind substrate.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables cobalt ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cobalt ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cobalt ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cobalt ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables magnesium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nickel cation transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nickel cation transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cobalt ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cobalt ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cobalt ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in magnesium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within magnesium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in magnesium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within magnesium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nickel cation transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ni(2(+))/Co(2(+))/Mg(2(+)) transporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4001426..4002376
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418260.1 Ni(2(+))/Co(2(+))/Mg(2(+)) transporter [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418260.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AMM6
      Conserved Domains (1) summary
      PRK11085
      Location:1 → 316
      PRK11085; magnesium/cobalt transporter CorA
    Nucleotide Protein
    Heading Accession and Version

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