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    ubiE bifunctional 2-octaprenyl-6-methoxy-1,4-benzoquinol methylase and demethylmenaquinone methyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948926, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ubiE
    Official Full Name
    bifunctional 2-octaprenyl-6-methoxy-1,4-benzoquinol methylase and demethylmenaquinone methyltransferase
    Primary source
    ECOCYC:EG11473
    Locus tag
    b3833
    See related
    ASAP:ABE-0012534
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3827; yigO
    Summary
    UbiE is the closest Escherichia coli homolog to B. stearothermophilus MenG (MenH, SP O86169). ubiE mutants accumulate DMK, not MK. rraA (menG) does not encode a methyltransferase. [More information is available at EcoGene: EG11473]. The ubiE gene product, a C-methyltransferase, catalyzes reactions in both ubiquinone (Q) and menaquinone (MK) biosynthesis. [More information is available at EcoCyc: EG11473].
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    Genomic context

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    Sequence:
    NC_000913.3 (4018855..4019610)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene uridine phosphorylase Neighboring gene putative recombination limiting protein RmuC Neighboring gene ubiquinone biosynthesis accessory factor UbiJ Neighboring gene ncRNA Neighboring gene ubiquinone biosynthesis protein UbiB Neighboring gene twin arginine protein translocation system - TatA protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An Escherichia coli mutant containing only demethylmenaquinone, but no menaquinone: effects on fumarate, dimethylsulfoxide, trimethylamine N-oxide and nitrate respiration. Wissenbach U, et al. Arch Microbiol, 1992. PMID 1444716
    2. Changes in the redox state and composition of the quinone pool of Escherichia coli during aerobic batch-culture growth. Bekker M, et al. Microbiology (Reading), 2007 Jun. PMID 17526854
    3. Characterization and genetic analysis of mutant strains of Escherichia coli K-12 accumulating the biquinone precursors 2-octaprenyl-6-methoxy-1,4-benzoquinone and 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone. Young IG, et al. J Bacteriol, 1971 Mar. PMID 4323297, Free PMC Article
    4. Role of respiration and glutathione in cadmium-induced oxidative stress in Escherichia coli K-12. Pacheco CC, et al. Arch Microbiol, 2008 Mar. PMID 17968530
    5. Aerobic respiration in mutants of Escherichia coli accumulating quinone analogues of ubiquinone. Wallace BJ, et al. Biochim Biophys Acta, 1977 Jul 7. PMID 195601

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study reports the identification and characterization of MenH (or YfbB), an enzyme previously proposed to catalyze a late step in menaquinone biosynthesis, as the (1 R,6 R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
      Title: Identification and characterization of (1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase in the menaquinone biosynthesis of Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables demethylmenaquinone methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aerobic respiration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in menaquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within menaquinone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ubiquinone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ubiquinone biosynthesis complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bifunctional 2-octaprenyl-6-methoxy-1,4-benzoquinol methylase and demethylmenaquinone methyltransferase
    YP_026269.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4018855..4019610
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_026269.1 bifunctional 2-octaprenyl-6-methoxy-1,4-benzoquinol methylase and demethylmenaquinone methyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for YP_026269.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376FRS0
      Conserved Domains (1) summary
      PRK00216
      Location:13 → 251
      ubiE; bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE
    Nucleotide Protein
    Heading Accession and Version

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