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    zraS sensor histidine kinase ZraS [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948506, updated on 3-Dec-2024

    Summary

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    Official Symbol
    zraS
    Official Full Name
    sensor histidine kinase ZraS
    Primary source
    ECOCYC:EG10008
    Locus tag
    b4003
    See related
    ASAP:ABE-0013088
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3995; hydH
    Summary
    ZraS belongs to the two component system ZraS/ZraR , is a sensor-histidine kinase and is known to be a transmembrane protein composed of three domains: external sensory domain (amino-terminal), cytoplasmic transmitter domain (carboxyl-terminal) and transmembrane hydrofobic central domain (unknown funtion). [More information is available at EcoCyc: EG10008].
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    Genomic context

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    Sequence:
    NC_000913.3 (4201926..4203323)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1481 domain-containing protein YjaH Neighboring gene signaling pathway modulator ZraP Neighboring gene DNA-binding transcriptional activator ZraR Neighboring gene phosphoribosylamine--glycine ligase Neighboring gene bifunctional AICAR transformylase/IMP cyclohydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A structure-function study of ZraP and ZraS provides new insights into the two-component system Zra. Taher R, et al. Biochim Biophys Acta Gen Subj, 2021 Mar. PMID 33309686
    2. Biophysical and physiological characterization of ZraP from Escherichia coli, the periplasmic accessory protein of the atypical ZraSR two-component system. Petit-Härtlein I, et al. Biochem J, 2015 Dec 1. PMID 26438879
    3. Initial cloning and sequencing of hydHG, an operon homologous to ntrBC and regulating the labile hydrogenase activity in Escherichia coli K-12. Stoker K, et al. J Bacteriol, 1989 Aug. PMID 2666400, Free PMC Article
    4. The Two-Component System ZraPSR Is a Novel ESR that Contributes to Intrinsic Antibiotic Tolerance in Escherichia coli. Rome K, et al. J Mol Biol, 2018 Dec 7. PMID 30389436
    5. The hydH/G Genes from Escherichia coli code for a zinc and lead responsive two-component regulatory system. Leonhartsberger S, et al. J Mol Biol, 2001 Mar 16. PMID 11243806

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A structure-function study of ZraP and ZraS provides new insights into the two-component system Zra.
      Title: A structure-function study of ZraP and ZraS provides new insights into the two-component system Zra.
    2. Results demonstrate that the expression of ZraS is induced by antimicrobials to which the mutants are more sensitive, underlying the function of whole ZraPSR system in response to the antimicrobials.
      Title: The Two-Component System ZraPSR Is a Novel ESR that Contributes to Intrinsic Antibiotic Tolerance in Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorelay sensor kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein histidine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to cell envelope stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to lead ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to zinc ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sensor histidine kinase ZraS
    NP_418431.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4201926..4203323
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418431.1 sensor histidine kinase ZraS [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418431.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1X3HZ19, A0A829LC44
      Conserved Domains (1) summary
      PRK10364
      Location:4 → 465
      PRK10364; two-component system sensor histidine kinase ZraS
    Nucleotide Protein
    Heading Accession and Version

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